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Fig. 4 | Cancer Cell International

Fig. 4

From: [6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling

Fig. 4

6-Paradol interacts with EGFR to exert suppression functions on proliferation and metastasis of pancreatic cancer cells. A PI3K-AKT signaling pathway and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance were correlated with 6-Paradol using KEGG pathway enrichment analysis. B The 3D structure of molecular docking between 6-Paradol and EGFR. C, D Western blot assays were performed to measure the effect of 6-Paradol (80 μM) on EGFR protein levels. EG Gain-Functional experiment was performed to measure the effect of 6-Paradol (80 μM) on proliferation and migration of 6-P + EGFR group in MIA PaCa-2 and SW1990 (scale bar: 100 μm). H, I Western blot was applied to investigate effect of 6-P combined with EGFR on EMT transition in MIA PaCa-2 and PANC-1. **p < 0.01

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