Fig. 1

CircRNA differential expression in HCC. A Heatmap showed differentially expressed circRNAs based on 7 pairs of circRNA for HCC and adjacent tissues in GSE97332 (Fold Change > 4 and P < 0.01). B Volcano plots were constructed based on GSE97332 (Fold Change > 4 and P < 0.01) The red points represent differentially upregulated genes, and green points represent downregulated genes. C, D Validation of circRNAs in tumor tissues and matched para-carcinoma tissues by qRT-PCR (***P < 0.001, **P < 0.01, *P < 0.05)