Fig. 2
From: Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
The regulatory mechanism of SBF2-AS1 in lung cancer. Upregulation of SBF2-AS1 expression could regulate lung cancer cell proliferation and invasion via different methods. SBF2-AS1 binds to subunits (EZH2 and SUZ12) of PRC2 to suppress the expression of P21 and augment cyclin D1 expression in NSCLC, thus promoting the cell cycle and EMT process. SBF2-AS1 facilitates NSCLC cell progression by regulating the miR-338-3p/ADAM17 axis. Moreover, SBF2-AS1 upregulated by E2F1 sponges miR-362-3p to promote GRB2 expression. Additionally, SBF2-AS1 enhances cell proliferation, migration and invasion via facilitating E2F1 through suppression of miR-362-3p/miR-338-3p