Fig. 3
From: Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers
The regulatory mechanism of SBF2-AS1 in digestive system neoplasms. SBF2-AS1 promotes tumorigenesis and tumor progression in digestive tumors. In HCC, SBF2-AS1 promotes tumor development by regulating the miR-140-5p/TGFBR1 axis or miR-145/SCAMP3 network. In addition, cell proliferation, migration and invasion are enhanced via upregulating HDAC3 expression by inhibition of miR-619-5p in CRC. SBF2-AS1 promotes PC progression and amplifies drug tolerance by regulating the miR-122-5P/XIAP or miR-142-3p/TWF1 axis. SBF2-AS1 competitively binds to miR-338-3/miR-362-3p thus increasing E2F1 expression in ESCC cells.Additionally, SBF2-AS1 facilitated ESCC progress via regulating miR-494/PFN2 axis. By binding to miR-545, SBF2-AS1 promotes GC development and augments EMS1 expression