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Table 2 Expression pattern and biological functions of SBF2-AS1 in human cancers

From: Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Cancer type Expression Biological Function Related genes Roles Refs
Acute myeloid leukemia Upregulated Proliferation, Cell cycle, Apoptosis miR-188-5p/ZFP91 Oncogene [38]
Breast cancer Upregulated Proliferation, cell cycle, invasion, migration, apoptosis miR-143/RRS1 Oncogene [35]
Lung cancer Upregulated Promote cell proliferation, invasion, migration SUZ12, p21, Cyclin D1 Oncogene [26]
Upregulated Enhance radiotherapy resistance (promote cell proliferation, inhibit apoptosis) miR-302a/MBNL3 Oncogene [42]
Upregulated Promote cell proliferation, invasion and migration miR-338-3p/ADAM17 Oncogene [50]
Upregulated Promote cell proliferation, invasion, migration E2F1/SBF2-AS1/miR-362-3p/GRB2 Oncogene [46]
Upregulated Promote cell cycle and cell proliferation miR-338-3p、miR-362-3p/E2F1 Oncogene [48]
Upregulated Promote cell proliferation, inhibit apoptosis FOXM1 Oncogene [47]
Osteosarcoma Upregulated Proliferation, invasion, migration miR-30a/FOXA1 Oncogene [44]
Pancreatic cancer Upregulated Promote cell proliferation, invasion, migration and EMT, inhibit apoptosis miR-142-3p/TWF1 Oncogene [27]
Upregulated Promote cell proliferation, invasion and migration, inhibit apoptosis miR-122-5p/XIAP Oncogene [43]
Cervical cancer Upregulated Proliferation, cell cycle, apoptosis miR-361-5p/FOXM1 Oncogene [39]
Colorectal cancer Upregulated Proliferation, invasion, migration miR-619-5p/HDAC3 Oncogene [30]
Papillary thyroid cancer Upregulated Proliferation, cell cycle,invasion, apoptosis miR-431-5p/CDK14 Oncogene [40]
Glioblastoma Upregulated Reduce temozolomide sensitivity, promote tumor cell DNA repair Z1B1/SBF2-AS1/miR-151-3p/XRCC4 Oncogene [37]
Upregulated Promote angiogenesis (enhance endothelial cells viability, migration and tube formation) NFAT5/miR-338-3p/EGFL7/ERK Oncogene [36]
Clear cell renal cell carcinoma Upregulated Proliferation, invasion, migration, apoptosis miR-338-3p/ETS1 Oncogene [41]
Hepatocellular carcinoma Upregulated Promote cell proliferation, invasion, migration and EMT miR-140-5p/TGFBR1 Oncogene [28]
Upregulated Promote cell migration and invasion miR-145-5p/SCAMP3 Oncogene [57]
Upregulated Promote cell proliferation, invasion, migration and EMT N-cadherin, vimentin Oncogene [29]
Gastric cancer Upregulated Proliferation, invasion, migration miR-545/EMS1 Oncogene [31]
Esophageal squamous cell carcinoma Upregulated Promote cell proliferation, invasion, migration and EMT, inhibit apoptosis miR-494/PFN2 Oncogene [33]
Upregulated Promote cell proliferation and inhibit apoptosis miR-338-3p/miR-362-3p/E2F1 Oncogene [34]
Upregulated Promote cell proliferation, invasion and migration CDKN1A Oncogene [32]