Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Lu, Qian; Lou, Jun; Cai, Ruyun; Han, Weidong; Pan, Hongming

doi:10.1186/s12935-021-02123-3

Cancer Cell International

Table 2 Expression pattern and biological functions of SBF2-AS1 in human cancers

From: Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers

Cancer type	Expression	Biological Function	Related genes	Roles	Refs
Acute myeloid leukemia	Upregulated	Proliferation, Cell cycle, Apoptosis	miR-188-5p/ZFP91	Oncogene	[38]
Breast cancer	Upregulated	Proliferation, cell cycle, invasion, migration, apoptosis	miR-143/RRS1	Oncogene	[35]
Lung cancer	Upregulated	Promote cell proliferation, invasion, migration	SUZ12, p21, Cyclin D1	Oncogene	[26]
	Upregulated	Enhance radiotherapy resistance (promote cell proliferation, inhibit apoptosis)	miR-302a/MBNL3	Oncogene	[42]
	Upregulated	Promote cell proliferation, invasion and migration	miR-338-3p/ADAM17	Oncogene	[50]
	Upregulated	Promote cell proliferation, invasion, migration	E2F1/SBF2-AS1/miR-362-3p/GRB2	Oncogene	[46]
	Upregulated	Promote cell cycle and cell proliferation	miR-338-3p、miR-362-3p/E2F1	Oncogene	[48]
	Upregulated	Promote cell proliferation, inhibit apoptosis	FOXM1	Oncogene	[47]
Osteosarcoma	Upregulated	Proliferation, invasion, migration	miR-30a/FOXA1	Oncogene	[44]
Pancreatic cancer	Upregulated	Promote cell proliferation, invasion, migration and EMT, inhibit apoptosis	miR-142-3p/TWF1	Oncogene	[27]
Pancreatic cancer	Upregulated	Promote cell proliferation, invasion and migration, inhibit apoptosis	miR-122-5p/XIAP	Oncogene	[43]
Cervical cancer	Upregulated	Proliferation, cell cycle, apoptosis	miR-361-5p/FOXM1	Oncogene	[39]
Colorectal cancer	Upregulated	Proliferation, invasion, migration	miR-619-5p/HDAC3	Oncogene	[30]
Papillary thyroid cancer	Upregulated	Proliferation, cell cycle,invasion, apoptosis	miR-431-5p/CDK14	Oncogene	[40]
Glioblastoma	Upregulated	Reduce temozolomide sensitivity, promote tumor cell DNA repair	Z1B1/SBF2-AS1/miR-151-3p/XRCC4	Oncogene	[37]
Glioblastoma	Upregulated	Promote angiogenesis (enhance endothelial cells viability, migration and tube formation)	NFAT5/miR-338-3p/EGFL7/ERK	Oncogene	[36]
Clear cell renal cell carcinoma	Upregulated	Proliferation, invasion, migration, apoptosis	miR-338-3p/ETS1	Oncogene	[41]
Hepatocellular carcinoma	Upregulated	Promote cell proliferation, invasion, migration and EMT	miR-140-5p/TGFBR1	Oncogene	[28]
	Upregulated	Promote cell migration and invasion	miR-145-5p/SCAMP3	Oncogene	[57]
	Upregulated	Promote cell proliferation, invasion, migration and EMT	N-cadherin, vimentin	Oncogene	[29]
Gastric cancer	Upregulated	Proliferation, invasion, migration	miR-545/EMS1	Oncogene	[31]
Esophageal squamous cell carcinoma	Upregulated	Promote cell proliferation, invasion, migration and EMT, inhibit apoptosis	miR-494/PFN2	Oncogene	[33]
	Upregulated	Promote cell proliferation and inhibit apoptosis	miR-338-3p/miR-362-3p/E2F1	Oncogene	[34]
	Upregulated	Promote cell proliferation, invasion and migration	CDKN1A	Oncogene	[32]

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