Fig. 3

High expression of NAT10 indicated shorted OS in 267 patients according to IHC analysis. a Representative images of H&E and IHC staining of NAT10. b Representative images of NAT10 staining in tumour and normal epithelial cells. c The patients with high expression of NAT10 had a lower OS rate than those with low and no expression of NAT10 (log-rank test, P = 0.001; high expression of NAT10 was detected in 156 patients, low expression of NAT10 was detected in 83 patients, and no NAT10 expression was detected in 28 patients). d Older patients (greater than 65 years old) had a lower OS rate in our cohort (log-rank test, P < 0.001). e Patients with advanced stage (III and IV stages) had a lower OS rate (log-rank test, P = 0.008). f Patients infected with HPV had a higher OS rate (log-rank test, P < 0.014). g Tumour recurrence was an unfavorable factor for OS in HNSCC (log-rank test, P < 0.001)