Table 4 Univariate and multivariate cox regression analysis of AFD, TMB and overall survival in patients with LUAD
Variables | Patients (N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |||
Training group | ||||||
 Sex | Female/Male | 27/27 | 1.581 (0.44–5.61) | 0.47 | 0.33 (0.025–4.49) | 0.40 |
 Age |  ≤ 60/ > 60 | 24/30 | 1.03 (0.96–1.10) | 0.31 | 0.99 (0.91–1.079) | 0.89 |
 Tumor_size |  ≤ 2/ > 2 | 28/27 | 1.279 (0.81–2.00) | 0.28 | 1.2 (0.677–2.395) | 0.45 |
 Smoking | N/(F/C) | 36/18 | 0.467 (0.13–1.61) | 0.22 | 0.20 (0.017–2.45) | 0.21 |
 pT | T1/ T2 | 35/19 | 1.297 (0.366–4.6) | 0.68 | 0.63 (0.104—3.7) | 0.61 |
 TMB |  < 22/ ≥ 22 | 40/14 | 1.088 ( 0.96–1.23) | 0.17 | 1.064 (0.90–1.25) | 0.44 |
 AFD |  < 17.9 / ≥ 17.9 | 40/14 | 1.100 (1.008–1.2) | 0.03 | 1.125 (1.001–1.26) | 0.04 |
Validation group | ||||||
 Sex | Female/Male | 26/22 | 0.17 (0.021–1.48) | 0.11 | 0.013 (0.003–0.46) | 0.017 |
 Age |  ≤ 60/ > 60 | 19/29 | 0.97 (0.91–1.04) | 0.48 | 0.975 (0.87–1.089) | 0.65 |
 Tumor_size |  ≤ 2/ > 2 | 23/25 | 2.5 (1.15–5.54) | 0.02 | 1.3 (0.25–6.61) | 0.75 |
Smoking | N/(F/C) | 35/13 | 0.87 (0.17–4.52) | 0.87 | 0.06 (0.002–2.15) | 0.12 |
 pT | T1/ T2/T4 | 32/15/1 | 1.52 (0.63–3.83) | 0.37 | 3.5 (0.094–0.99) | 0.49 |
 AFD |  < 16.76/ ≥ 16.76 | 36/12 | 3.1 (1.4–6.60) | 0.003 | 4.62 (1.22–17.4) | 0.02 |