Skip to main content

Table 4 Univariate and multivariate cox regression analysis of AFD, TMB and overall survival in patients with LUAD

From: Allele frequency deviation (AFD) as a new prognostic model to predict overall survival in lung adenocarcinoma (LUAD)

Variables Patients (N) Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P
Training group
 Sex Female/Male 27/27 1.581 (0.44–5.61) 0.47 0.33 (0.025–4.49) 0.40
 Age  ≤ 60/ > 60 24/30 1.03 (0.96–1.10) 0.31 0.99 (0.91–1.079) 0.89
 Tumor_size  ≤ 2/ > 2 28/27 1.279 (0.81–2.00) 0.28 1.2 (0.677–2.395) 0.45
 Smoking N/(F/C) 36/18 0.467 (0.13–1.61) 0.22 0.20 (0.017–2.45) 0.21
 pT T1/ T2 35/19 1.297 (0.366–4.6) 0.68 0.63 (0.104—3.7) 0.61
 TMB  < 22/ ≥ 22 40/14 1.088 ( 0.96–1.23) 0.17 1.064 (0.90–1.25) 0.44
 AFD  < 17.9 / ≥ 17.9 40/14 1.100 (1.008–1.2) 0.03 1.125 (1.001–1.26) 0.04
Validation group
 Sex Female/Male 26/22 0.17 (0.021–1.48) 0.11 0.013 (0.003–0.46) 0.017
 Age  ≤ 60/ > 60 19/29 0.97 (0.91–1.04) 0.48 0.975 (0.87–1.089) 0.65
 Tumor_size  ≤ 2/ > 2 23/25 2.5 (1.15–5.54) 0.02 1.3 (0.25–6.61) 0.75
Smoking N/(F/C) 35/13 0.87 (0.17–4.52) 0.87 0.06 (0.002–2.15) 0.12
 pT T1/ T2/T4 32/15/1 1.52 (0.63–3.83) 0.37 3.5 (0.094–0.99) 0.49
 AFD  < 16.76/ ≥ 16.76 36/12 3.1 (1.4–6.60) 0.003 4.62 (1.22–17.4) 0.02
  1. Bold values indicate the significant values < 0.05
  2. CI, confidence interval; C, current; F, Former; HR, hazard ratio; N, Never