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Fig. 4 | Cancer Cell International

Fig. 4

From: DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling

Fig. 4

DDX52 affects the activation of c-Myc signaling in PCa. a, c Gene set enrichment analysis (GSEA) performed based on hallmark gene sets indicated that the c-Myc-upregulated gene set was the most significantly enriched in patients with high DDX52 expression in the indicated PCa cohorts. The results are shown in rank order according to the normalized enrichment score and the p-value. b, d The c-Myc-upregulated gene set was used to perform GSEA for the respective datasets based on the DDX52 transcription level. e, f GSEA of the expression profiles obtained from RNA sequencing of 22RV1 (e) or PC3 (f) cells with (shDDX52, right) or without (shCON, left) DDX52 knocked down based on the c-Myc-upregulated gene set.

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