Fig. 8

Potential mechanism for how lnc-Ma301 regulates the proliferation and migration of HCC cells. A, a Akt, Erk1, and caprin-1 expression at mRNA level when lnc-Ma301 was overexpressed or silenced in SMMC7721 cells. b Akt, Erk1, and caprin-1 protein levels when lnc-Ma301 was overexpressed or silenced in SMMC7721 cells. c Akt and Erk1 protein levels when caprin-1 was silenced in SMMC7721 cells. B Akt and Erk1 mRNA and protein levels when lnc-Ma301 interacted with caprin-1 in SMMC7721 cells. C Schematic diagram of the potential mechanism of action of lnc-Ma301 on the proliferation and migration of HCC cells. lnc-Ma301 interacts with caprin-1 to inhibit HCC metastasis and EMT via the Akt/Erk1 pathway. Data are presented as mean ± standard error of the mean (SEM). *P < 0.05