Table 2 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, obtained from healthy and tumour tissue
From: Ultrastructural analysis of breast cancer patient-derived organoids
Healthy | Tumour | P value | |
|---|---|---|---|
Mitochondria with peripheral ridges | |||
Yes | 11 (91.66%) | 13 (18.84%) | 0.01 |
No | 1 (8.34%) | 56 (81.16%) | |
Intracellular lumens | |||
Yes | 4 (33.33%) | 37 (53.62%) | 0.23 |
No | 8 (66.67%) | 32 (46.38%) | |
Intercellular lumens | |||
Yes | 12 (100%) | 67 (97.10%) | 1 |
No | 0 (0%) | 2 (2.90%) | |
“Virus like” microvesicles | |||
Yes | 3 (25%) | 18 (26.08%) | 1 |
No | 9 (75%) | 51 (73.92%) | |
Open desmosomes | |||
Yes | 4 (33.33%) | 21 (30.43%) | 1 |
No | 8 (66.67%) | 48 (69.57%) | |
Intercellular debris | |||
Yes | 5 (41.66%) | 30 (43.47%) | 1 |
No | 7 (58.34%) | 39 (56.53%) | |
Polylobed nuclei | |||
Yes | 5 (41.66%) | 21 (30.43%) | 0.51 |
No | 7 (58.34%) | 48 (69.57%) | |
Lysosomes | |||
Yes | 6 (50%) | 22 (31.88%) | 0.32 |
No | 6 (50%) | 47 (68.12%) | |
Secretory granules | |||
Yes | 9 (75%) | 50 (72.46%) | 1 |
No | 3 (25%) | 19 (27.54%) | |