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Table 2 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, obtained from healthy and tumour tissue

From: Ultrastructural analysis of breast cancer patient-derived organoids

  Healthy Tumour P value
Mitochondria with peripheral ridges
 Yes 11 (91.66%) 13 (18.84%) 0.01
 No 1 (8.34%) 56 (81.16%)  
Intracellular lumens
 Yes 4 (33.33%) 37 (53.62%) 0.23
 No 8 (66.67%) 32 (46.38%)  
Intercellular lumens
 Yes 12 (100%) 67 (97.10%) 1
 No 0 (0%) 2 (2.90%)  
“Virus like” microvesicles
 Yes 3 (25%) 18 (26.08%) 1
 No 9 (75%) 51 (73.92%)  
Open desmosomes
 Yes 4 (33.33%) 21 (30.43%) 1
 No 8 (66.67%) 48 (69.57%)  
Intercellular debris
 Yes 5 (41.66%) 30 (43.47%) 1
 No 7 (58.34%) 39 (56.53%)  
Polylobed nuclei
 Yes 5 (41.66%) 21 (30.43%) 0.51
 No 7 (58.34%) 48 (69.57%)  
Lysosomes
 Yes 6 (50%) 22 (31.88%) 0.32
 No 6 (50%) 47 (68.12%)  
Secretory granules
 Yes 9 (75%) 50 (72.46%) 1
 No 3 (25%) 19 (27.54%)