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Table 3 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, obtained from different histological tumour subtypes

From: Ultrastructural analysis of breast cancer patient-derived organoids

  IDC ILC DCIS
Mitochondria with peripheral ridges
 Yes 11 (18.64%) 2 (25%) 0 (0%)
 No 48 (81.36%) 6 (75%) 2 (100%)
Intracellular lumens
 Yes 30 (50.84%) 6 (75%) 1 (50%)
 No 29 (49.16%) 2 (25%) 1 (50%)
Intercellular lumens
 Yes 57 (96.61%) 8 (100%) 2 (100%)
 No 2 (3.39%) 0 (0%) 0 (0%)
“Virus like” microvesicles
 Yes 17 (28.81%) 0 (0%) 1 (50%)
 No 42 (71.19%) 8 (100%) 1 (50%)
Open desmosomes
 Yes 18 (30.51%) 2 (25%) 1 (50%)
 No 41 (69.49%) 6 (75%) 1 (50%)
Intercellular debris
 Yes 26 (44.06%) 4 (50%) 0 (0%)
 No 33 (55.94%) 4 (50%) 2 (100%)
Polylobed nuclei
 Yes 20 (33.89%) 1 (12.5%) 0 (0%)
 No 39 (66.11%) 7 (87.5%) 2 (100%)
Lysosomes
 Yes 22 (37.28%) 0 (0%) 0 (0%)
 No 37 (62.72%) 8 (100%) 2 (100%)
Secretory granules
 Yes 43 (72.88%) 6 (75%) 1 (50%)
 No 16 (27.12%) 2 (25%) 1 (50%)