Table 3 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, obtained from different histological tumour subtypes
From: Ultrastructural analysis of breast cancer patient-derived organoids
IDC | ILC | DCIS | |
|---|---|---|---|
Mitochondria with peripheral ridges | |||
Yes | 11 (18.64%) | 2 (25%) | 0 (0%) |
No | 48 (81.36%) | 6 (75%) | 2 (100%) |
Intracellular lumens | |||
Yes | 30 (50.84%) | 6 (75%) | 1 (50%) |
No | 29 (49.16%) | 2 (25%) | 1 (50%) |
Intercellular lumens | |||
Yes | 57 (96.61%) | 8 (100%) | 2 (100%) |
No | 2 (3.39%) | 0 (0%) | 0 (0%) |
“Virus like” microvesicles | |||
Yes | 17 (28.81%) | 0 (0%) | 1 (50%) |
No | 42 (71.19%) | 8 (100%) | 1 (50%) |
Open desmosomes | |||
Yes | 18 (30.51%) | 2 (25%) | 1 (50%) |
No | 41 (69.49%) | 6 (75%) | 1 (50%) |
Intercellular debris | |||
Yes | 26 (44.06%) | 4 (50%) | 0 (0%) |
No | 33 (55.94%) | 4 (50%) | 2 (100%) |
Polylobed nuclei | |||
Yes | 20 (33.89%) | 1 (12.5%) | 0 (0%) |
No | 39 (66.11%) | 7 (87.5%) | 2 (100%) |
Lysosomes | |||
Yes | 22 (37.28%) | 0 (0%) | 0 (0%) |
No | 37 (62.72%) | 8 (100%) | 2 (100%) |
Secretory granules | |||
Yes | 43 (72.88%) | 6 (75%) | 1 (50%) |
No | 16 (27.12%) | 2 (25%) | 1 (50%) |