Table 4 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, stratified for molecular subtype
From: Ultrastructural analysis of breast cancer patient-derived organoids
Luminal A/B | HER 2+ | Basal-like | |
|---|---|---|---|
Mitochondria with peripheral ridges | |||
Yes | 12 (22.64%) | 0 (0%) | 1 (14.28%) |
No | 41 (77.36%) | 9 (100%) | 6 (85.72%) |
Intracellular lumens | |||
Yes | 28 (52.83%) | 7 (77.77%) | 2 (28.57%) |
No | 25 (47.17%) | 2 (22.23%) | 5 (71.43%) |
Intercellular lumens | |||
Yes | 52 (98.11%) | 9 (100%) | 6 (85.72%) |
No | 1 (1.89%) | 0 (0%) | 1 (14.28%) |
“Virus like” microvesicles | |||
Yes | 15 (28.30%) | 2 (22.23%) | 1 (14.28%) |
No | 38 (71.70%) | 7 (77.77%) | 6 (85.72%) |
Open desmosomes | |||
Yes | 18 (33.96%) | 1 (11.11%) | 2 (28.57%) |
No | 35 (66.04%) | 8 (88.89%) | 5 (71.43%) |
Intercellular debris | |||
Yes | 19 (35.84%) | 7 (77.77%) | 4 (57.14%) |
No | 34 (64.16%) | 2 (22.23%) | 3 (42.86%) |
Polylobed nuclei | |||
Yes | 15 (28.30%) | 3 (33.33%) | 3 (42.86%) |
No | 38 (71.70%) | 6 (66.67%) | 4 (57.14%) |
Lysosomes | |||
Yes | 15 (28.30%) | 5 (55.55%) | 2 (28.57%) |
No | 38 (71.70%) | 4 (44.45%) | 5 (71.43%) |
Secretory granules | |||
Yes | 39 (73.58%) | 7 (77.77%) | 4 (57.14%) |
No | 14 (26.42%) | 2 (22.23%) | 3 (42.86%) |