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Table 4 Summary of frequencies in which these morphological parameters have been observed in mammary PDO, stratified for molecular subtype

From: Ultrastructural analysis of breast cancer patient-derived organoids

  Luminal A/B HER 2+ Basal-like
Mitochondria with peripheral ridges
 Yes 12 (22.64%) 0 (0%) 1 (14.28%)
 No 41 (77.36%) 9 (100%) 6 (85.72%)
Intracellular lumens
 Yes 28 (52.83%) 7 (77.77%) 2 (28.57%)
 No 25 (47.17%) 2 (22.23%) 5 (71.43%)
Intercellular lumens
 Yes 52 (98.11%) 9 (100%) 6 (85.72%)
 No 1 (1.89%) 0 (0%) 1 (14.28%)
“Virus like” microvesicles
 Yes 15 (28.30%) 2 (22.23%) 1 (14.28%)
 No 38 (71.70%) 7 (77.77%) 6 (85.72%)
Open desmosomes
 Yes 18 (33.96%) 1 (11.11%) 2 (28.57%)
 No 35 (66.04%) 8 (88.89%) 5 (71.43%)
Intercellular debris
 Yes 19 (35.84%) 7 (77.77%) 4 (57.14%)
 No 34 (64.16%) 2 (22.23%) 3 (42.86%)
Polylobed nuclei
 Yes 15 (28.30%) 3 (33.33%) 3 (42.86%)
 No 38 (71.70%) 6 (66.67%) 4 (57.14%)
Lysosomes
 Yes 15 (28.30%) 5 (55.55%) 2 (28.57%)
 No 38 (71.70%) 4 (44.45%) 5 (71.43%)
Secretory granules
 Yes 39 (73.58%) 7 (77.77%) 4 (57.14%)
 No 14 (26.42%) 2 (22.23%) 3 (42.86%)