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Table 3 Molecular function of lncRNA in OC

From: Ovarian cancer: epigenetics, drug resistance, and progression

LncRNA Adjust Resistance against Function Target/pathway
HOTAIR Cisplatin Correlates with DNA damage response and senescence NF-κB [70];
HOXA7 [146];
miR-200c [147];
P65, caspase 3/9 [148];
MMP9, MMP3, E-cadherin, vimentin, snail [69];
Wnt/β-catenin [149];
H19 Cisplatin Promotion of cell migration and invasion IGF2 [79];
EZH2, P21, PTEN [150];
miR-370-3p [151];
let-7 [80];
miR-370-3p-TGF-beta [151];
MALAT1 Cisplatin Promotion of cell proliferation, migration, and invasion Notch1 [76];
miR-200c [90];
PI3K/AKT pathway [77];
MEG3 Cisplatin Tumor suppressor EMT [152];
miR-214 [86];
UCA1 Paclitaxel Cisplatin Apoptosis; drug effluent system miR-143/FOSL2 pathway [153];
XIST Cisplatin Promotion of cell proliferation, migration, and invasion hsa-miR-214-3p [93];
BC200 Carboplatin Tumor suppressor Inhibited cell proliferation and increased the sensitivity of OC cells to carboplatin [154];
LSINCT5 Paclitaxel Promotion of cell proliferation, migration, and invasion CXCL12/CXCR4 [155];
DNM3OS Cisplatin Promotion of cell proliferation, migration, and invasion EMT [152];
NEAT1 Paclitaxel Promotion of cell proliferation and metastasis
Inhibition of apoptosis
miR-383-3p [95];
ZEB1 [81];
ANRIL Cisplatin Promotion of cell proliferation and cell cycle progression let-7a/HMGA2 [83];
GAS5 Platinum Induction of apoptosis cyclin D1, p21, APAF1 [85];
  1. ↓: Downregulated; ↑: Upregulated