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Table 3 Molecular function of lncRNA in OC

From: Ovarian cancer: epigenetics, drug resistance, and progression

LncRNA

Adjust

Resistance against

Function

Target/pathway

HOTAIR

↑

Cisplatin

Correlates with DNA damage response and senescence

NF-κB [70];

HOXA7 [146];

miR-200c [147];

P65, caspase 3/9 [148];

MMP9, MMP3, E-cadherin, vimentin, snail [69];

Wnt/β-catenin [149];

H19

↑

Cisplatin

Promotion of cell migration and invasion

IGF2 [79];

EZH2, P21, PTEN [150];

miR-370-3p [151];

let-7 [80];

miR-370-3p-TGF-beta [151];

MALAT1

↑

Cisplatin

Promotion of cell proliferation, migration, and invasion

Notch1 [76];

miR-200c [90];

PI3K/AKT pathway [77];

MEG3

↓

Cisplatin

Tumor suppressor

EMT [152];

miR-214 [86];

UCA1

↑

Paclitaxel Cisplatin

Apoptosis; drug effluent system

miR-143/FOSL2 pathway [153];

XIST

↑

Cisplatin

Promotion of cell proliferation, migration, and invasion

hsa-miR-214-3p [93];

BC200

↓

Carboplatin

Tumor suppressor

Inhibited cell proliferation and increased the sensitivity of OC cells to carboplatin [154];

LSINCT5

↑

Paclitaxel

Promotion of cell proliferation, migration, and invasion

CXCL12/CXCR4 [155];

DNM3OS

↑

Cisplatin

Promotion of cell proliferation, migration, and invasion

EMT [152];

NEAT1

↑

Paclitaxel

Promotion of cell proliferation and metastasis

Inhibition of apoptosis

miR-383-3p [95];

ZEB1 [81];

ANRIL

↑

Cisplatin

Promotion of cell proliferation and cell cycle progression

let-7a/HMGA2 [83];

GAS5

↓

Platinum

Induction of apoptosis

cyclin D1, p21, APAF1 [85];

  1. ↓: Downregulated; ↑: Upregulated