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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA CTD-3252C9.4 modulates pancreatic cancer cell survival and apoptosis through regulating IFI6 transcription

Fig. 4

LncRNA CTD-3252C9.4 down-regulates IFI6 expression in pancreatic cancer cell lines. A Left: Venn diagram analysis of three independent HTS reveals 11 shared potential targets of CTD-3252C9.4. Right: 11 potential target genes were detected in CTD-3252C9.4-overexpressing Panc-1 cells. Relative IFI6 mRNA (B) and protein (C) levels in CTD-3252C9.4-overexpressing or CTD-3252C9.4-knocked down Panc-1 and MIApaca-2 cells. D Relative expression of IFI6 was detected in different pancreatic cancer cells and PCSCs. E Representative images of IFI6 immunohistochemical staining of the tumor sections. Relative expression of IFI6 was detected in 20 non-paired (F) or paired (G) pancreatic cancer tissues and the adjacent normal tissues. H Spearman correlation analysis of the fold changes of CTD-3252C9.4 and IFI6 mRNA in 20 paired pancreatic cancer tissues and the adjacent normal tissues. All data are shown as the mean ± SEM. *P < 0.05 and **P < 0.01 by two-tailed Student’s t-test

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