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Table 1 Clinicopathologic features between nuclear BCL10-negative and nuclear BCL10-positive groups of patients with PDAC

From: Contribution of nuclear BCL10 expression to tumor progression and poor prognosis of advanced and/or metastatic pancreatic ductal adenocarcinoma by activating NF-κB-related signaling

 

Nuclear BCL10 expression

Total (N)

Negative

Positive

p-value

Number

136

78 (57.4%)

58 (42.6%)

 

Age

   

0.837

 Median

59.0

58.0

61.0

 

 Range

27–82

35–82

27–76

 

Sex

   

0.102

 Men

83 (61.0%)

43 (55.1%)

40 (69.0%)

 

 Women

53 (39.0%)

35 (44.9%)

18 (31.0%)

 

Smoking

   

0.262

 No

87 (64.0%)

53 (67.9%)

34 (58.6%)

 

 Yes

49 (36/0%)

25 (32.1%)

24 (41.4%)

 

Alcohol

   

0.937

 No

98 (72.1%)

56 (71.8%)

42 (72.4%)

 

 Yes

38 (27.9%)

22 (28.2%)

16 (27.6%)

 

Stage

   

0.743§

 Recurrent

37 (27.2%)

23 (29.5%)

14 (24.1%)

 

 Stage IIIB

19 (14.0%)

9 (11.5%)

10 (17.2%)

 

 Stage IV

80 (58.8%)

46 (59.0%)

34 (58.6%)

 

Metastases

   

0.667§

 Peritoneal

12 (8.8%)

7 (9.0%)

5 (9.6%)

 

 Liver

83 (61.0%)

47 (60.2%)

36 (62.1%)

 

 Other sitesa

23 (16.9%)

12 (15.4%)

11 (19.0%)

 

 Regional LNs

18 (13.2%)

12 (15.4%)

6 (10.3%)

 

Chemotherapy

   

0.306

 Gem-alone

44 (32.4%)

28 (35.9%)

16 (27.6%)

 

 Gem-based

92 (67.6%)

50 (61.1%)

42 (72.4%)

 

Response

   

0.423§

 CR + PR

11 (8.1%)

6 (7.7%)

5 (8.6%)

 

 SD + PD

85 (62.5%)

51 (65.4%)

34 (58.6%)

 

 NA

40 (29.4%)

21 (26.9%)

19 (32.8%)

 

NF-κB expressionb

   

 < 0.001

 Negative

58 (61.1%)

49 (84.5%)

9 (24.3%)

 

 Positive

37 (38.9%)

9 (15.5%)

28 (75.7%)

 
  1. PDAC pancreatic ductal adenocarcinoma, N number, LNs lymph nodes, Gem gemcitabine, CR complete remission, PR partial remission, SD stable disease, PD progressive disease, NA non-analyses or difficult to assess the response
  2. aOther sites: included extra-liver lesions, such as lung, adrenal gland metastases
  3. bNF-κB expression was examined in tumor cells of selected 95 cases of PDAC
  4. P values (2-sided) were calculated using the Student t test
  5. P values (2-sided) were calculated using the Χ2 test or the Fisher exact test
  6. §P values (2-sided) were calculated using 1-way analysis of variance