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Table 1 Clinicopathologic features between nuclear BCL10-negative and nuclear BCL10-positive groups of patients with PDAC

From: Contribution of nuclear BCL10 expression to tumor progression and poor prognosis of advanced and/or metastatic pancreatic ductal adenocarcinoma by activating NF-κB-related signaling

  Nuclear BCL10 expression
Total (N) Negative Positive p-value
Number 136 78 (57.4%) 58 (42.6%)  
Age     0.837
 Median 59.0 58.0 61.0  
 Range 27–82 35–82 27–76  
Sex     0.102
 Men 83 (61.0%) 43 (55.1%) 40 (69.0%)  
 Women 53 (39.0%) 35 (44.9%) 18 (31.0%)  
Smoking     0.262
 No 87 (64.0%) 53 (67.9%) 34 (58.6%)  
 Yes 49 (36/0%) 25 (32.1%) 24 (41.4%)  
Alcohol     0.937
 No 98 (72.1%) 56 (71.8%) 42 (72.4%)  
 Yes 38 (27.9%) 22 (28.2%) 16 (27.6%)  
Stage     0.743§
 Recurrent 37 (27.2%) 23 (29.5%) 14 (24.1%)  
 Stage IIIB 19 (14.0%) 9 (11.5%) 10 (17.2%)  
 Stage IV 80 (58.8%) 46 (59.0%) 34 (58.6%)  
Metastases     0.667§
 Peritoneal 12 (8.8%) 7 (9.0%) 5 (9.6%)  
 Liver 83 (61.0%) 47 (60.2%) 36 (62.1%)  
 Other sitesa 23 (16.9%) 12 (15.4%) 11 (19.0%)  
 Regional LNs 18 (13.2%) 12 (15.4%) 6 (10.3%)  
Chemotherapy     0.306
 Gem-alone 44 (32.4%) 28 (35.9%) 16 (27.6%)  
 Gem-based 92 (67.6%) 50 (61.1%) 42 (72.4%)  
Response     0.423§
 CR + PR 11 (8.1%) 6 (7.7%) 5 (8.6%)  
 SD + PD 85 (62.5%) 51 (65.4%) 34 (58.6%)  
 NA 40 (29.4%) 21 (26.9%) 19 (32.8%)  
NF-κB expressionb      < 0.001
 Negative 58 (61.1%) 49 (84.5%) 9 (24.3%)  
 Positive 37 (38.9%) 9 (15.5%) 28 (75.7%)  
  1. PDAC pancreatic ductal adenocarcinoma, N number, LNs lymph nodes, Gem gemcitabine, CR complete remission, PR partial remission, SD stable disease, PD progressive disease, NA non-analyses or difficult to assess the response
  2. aOther sites: included extra-liver lesions, such as lung, adrenal gland metastases
  3. bNF-κB expression was examined in tumor cells of selected 95 cases of PDAC
  4. P values (2-sided) were calculated using the Student t test
  5. P values (2-sided) were calculated using the Χ2 test or the Fisher exact test
  6. §P values (2-sided) were calculated using 1-way analysis of variance