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Table 1. MiRNAs involved in STAT3 signaling pathway

From: Noncoding RNAs involved in the STAT3 pathway in glioma

MicroRNA Up-/down-regulation Role in glioma Biological functions Target gene Refs.
miR cluster MC‐let‐7a‐1 ~ let‐7d Down Tumor suppressor Inhibit proliferation, promote apoptosis, and cell autophagy STAT3 [40]
miR-506 Down Tumor suppressor Inhibit proliferation, migration, and invasion STAT3 [42]
miR-181d Down Tumor suppressor Inhibit migration and invasion STAT3/STAT5A [43]
miR-29b Down Tumor suppressor Inhibit chemoresistance STAT3 [45]
miR-519a Down Tumor suppressor Inhibit proliferation, migration, invasion, and chemoresistance STAT3 [46, 47]
miR-124 Down Tumor suppressor Inhibit proliferation, promote apoptosis, and immune therapeutics STAT3/SAMD4 [48, 56]
miR‐221/222 cluster Up Oncogene Promote migration, invasion, proliferation, and angiogenesis SOCS3 [50]
miR-30 Up Oncogene Promote tumorigenesis SOCS3 [51]
miR-125b Up Oncogene Promote chemoresistance PIAS3 [53]
miR-133a Down Tumor suppressor Inhibit proliferation, migration, and invasion, promote apoptosis CTGF [55]
miR-148a Up Oncogene Promote migration, invasion CADM1 [58]
miR-876-3p Down Tumor suppressor Inhibit proliferation, migration, and invasion KIF20A [60]
miR-26a Up Oncogene Promote chemoresistance, migration, invasion, proliferation AP-2α [62]
miR-6743-5p Up Oncogene Promote proliferation, inhibit apoptosis GRIM-19 [63]
miR-1246 Up Oncogene Promote proliferation, migration, and invasion TERF2IP [65]
miR-125b/miR-20b Up Oncogene Promote proliferation FZD6/ALDH1A3 [67]
miR-21 Up Oncogene Promote proliferation and invasion RECK [68, 69, 70, 71]
miR-182-5p Up Oncogene Promote proliferation, migration, and invasion PCDH8 [72]
miR-30b-3p Up Oncogene Promote proliferation, chemoresistance, and inhibit apoptosis RHOB [73]
miR-218 Down Tumor suppressor Inhibits proliferation PDGFRα [74]
miR-34a Down Tumor suppressor Inhibit migration and invasion [75]
miR-184 Up Oncogene Promote proliferation and invasion [76]
miR-203 Down Tumor suppressor Radiosensitivity [77]
miR-31 Down Tumor suppressor Promote apoptosis [78]
miR-27b Up Oncogene Promote invasion, proliferation, inhibit apoptosis [79]
miR-302/367 Down Tumor suppressor Inhibit proliferation, migration [80]