Knockdown lncRNA CRNDE enhances temozolomide chemosensitivity by regulating autophagy in glioblastoma

Table 2 Univariate and multivariate Cox proportional hazards regression model analysis of factors related to overall survival for patients

Characteristics	Univariate analysis			Multivariate analysis
Characteristics	HR	95% CI	P value	HR	95% CI	P value
Age (years)
< 55 vs. ≥ 55	0.947	0.628–1.298	0.683	–	–	–
Gender
Male vs. Female	0.752	0.451–1.364	0.464	–	–	–
Location
Supratentorial vs. Subtentorial	1.134	0.967–1.602	0.301	–	–	–
Tumor size (mm)
< 50 vs. ≥ 50	0.828	0.754–8.976	0.832	–	–	–
Peritumoral edema range (mm)
< 10 vs. ≥ 10	1.876	0.667–3.546	0.795	–	–	–
Histological grade
I + II vs. III + IV	0.392	0.265–0.769	0.024^*	0.492	0.328–0.893	0.040^*
Postoperative recurrence
No vs. Yes	0.487	0.291–0.896	0.039^*	0.537	0.314–0.915	0.043^*
CRNDE expression
High vs. Low	2.468	1.109–4.654	0.002^*	1.897	1.132–2.387	0.006^*

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