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Fig. 7 | Cancer Cell International

Fig. 7

From: Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5

Fig. 7

MiR-107 severed as a tumor repressor in EC cells by targeting SLC1A5. KYSE150 and TE1 cells were transfected with miR-NC, miR-107, miR-107 + pcDNA, miR-107 + SLC1A5. A Western blot was applied to assay the protein expression of SLC1A5. B–E MTT assay (B, C), colony formation assay (D) and EdU assay (E) were applied to analyze cell proliferation. F, G Flow cytometry and transwell assay were exploited to determine cell apoptosis (F) and invasion (G). H–J The glutamine consumption (H), α-ketoglutarate production (I) and glutamate production (J) by the detection kits were exploited to evaluate the glutamine metabolism. K, L Western blot was exploited to detect the protein levels of CyclinD1 and MMP9. **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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