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Fig. 3 | Cancer Cell International

Fig. 3

From: Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer

Fig. 3

Effects of miR-449a Exo on tumor cell proliferation and apoptosis. A The changes in cell viability of A549, Hela and HepG2 cells incubated with miR-449a Exo for 0, 24, 48, and 72 h was evaluated by CCK-8 assay. *P < 0.05, **P < 0.01. B EdU staining results of the incubation of A549 cells with exosomes. Scale bar = 100nm. ***P < 0.001. C Flow cytometric detection of apoptosis. **P < 0.01. D RT-qPCR detection of the relative expression levels of miR-449a and Bcl-2 in A549 cells. ***P < 0.001. E The protein expression level of Bcl-2 was evaluated by Western blot. ***P < 0.001

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