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Table 1 The roles of USP17 in different types of cancers

From: The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Cancer type Targets Functions References
Central nervous system cancer Ras and Myc Inhibits the carcinogenesis and proliferation of glioma [35]
CDC25A Negatively regulates cell cycle progression and proliferation of glioma [36]
Head and neck cancer BRD4/EZH2 Promotes the proliferation of OSCC cells and inhibits apoptosis [37]
Snail1 Promotes the epithelial mesenchymal transition (EMT) [38]
Thoracic cancer Cyclin A Drives cell cycle progression and promotes lung cancer cell proliferation [41]
Transferrin and its receptor (TfR) Promotes the growth of EGFR mutation lung cancer cells and inhibits apoptosis [43]
TRAF2 and TRAF3 Upregulates the inflammation-related genes and stemness-related genes in cancer cells [45]
HAS2 Triggers the progression of cancer [47]
MMP3 and MMP9 Promotes the tumorigenesis and growth [48]
PI3K/Akt Contributes to cisplatin resistance in NSCLC cells [49]
Breast cancer AEP Promotes the intracellular stability and metastasis [50]
SET8 Increases the proliferation of breast cancer cells [53]
Snail, Slug and Twist Promotes EMT and breast cancer metastasis; cancer stem cell-like characteristics of breast cancer cells [54, 56]
CDC25A Promotes cell cycle progression [58]
Geminin Enhances genomic instability, DNA replication change, aneuploidy, and cancer progression [61]
MAPK signaling pathway Decreases the cell viability [62]
Gastrointestinal cancer H2AX Overcomes DNA double-strand break (DSB) [66, 68]
DEC1 Recovers from G2 DNA damage checkpoint [69]
Nrf2 Leads to chemotherapy resistance [70]
Genitourinary cancer NF-κB/ROS Promotes the proliferation, migration, and invasion of prostate cancer cells and inhibits apoptosis [72]
BRD4 Leads to drug resistance of BET inhibitor [73]
Gynecologic cancer SDS3 Induces apoptosis and inhibits cell proliferation in cervical adenocarcinoma cells [74]
Ras Decreases growth of Hela cells [77]
ELK-1 Promotes cell proliferation [80]
Rho GTPases Promotes cell migration and cytoskeleton reorganization [81]
MCL1 Regulates chemoresistance in ovarian cancer [85]
Bone and soft tissue sarcomas Smad4 Enhances the migration and invasion of osteosarcoma cells through activation of EMT [86]
  1. AEP asparaginyl endopeptidase, Akt protein kinase B, BET bromodomain and extra-terminal domain, BRD4 bromodomain-containing protein 4, CDC25A cell division cycle 25A, DEC1 defective chorion-1, EGFR epidermal growth factor receptor, ELK-1 ETS-like protein 1, EZH2 enhancer of zeste homolog-2, H2AX H2A histone family member X, HAS2 hyaluronan synthase 2, MAPK mitogen-activated protein kinase, MCL1 myeloid cell leukemia sequence 1, MMP3 matrix metallopeptidase 3, OSCC oral squamous cell carcinoma, PI3K phosphoinositide-3-kinase, ROS reactive oxygen species, SDS3 suppressor of defective silencing 3, SET8 SET domain-containing protein 8, TRAFs tumor necrosis factor receptor associated factors