The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Yang, Guang-Fei; Zhang, Xin; Su, Yi-Ge; Zhao, Ren; Wang, Yan-Yang

doi:10.1186/s12935-021-02160-y

Cancer Cell International

Table 1 The roles of USP17 in different types of cancers

From: The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Cancer type	Targets	Functions	References
Central nervous system cancer	Ras and Myc	Inhibits the carcinogenesis and proliferation of glioma	[35]
Central nervous system cancer	CDC25A	Negatively regulates cell cycle progression and proliferation of glioma	[36]
Head and neck cancer	BRD4/EZH2	Promotes the proliferation of OSCC cells and inhibits apoptosis	[37]
Head and neck cancer	Snail1	Promotes the epithelial mesenchymal transition (EMT)	[38]
Thoracic cancer	Cyclin A	Drives cell cycle progression and promotes lung cancer cell proliferation	[41]
	Transferrin and its receptor (TfR)	Promotes the growth of EGFR mutation lung cancer cells and inhibits apoptosis	[43]
	TRAF2 and TRAF3	Upregulates the inflammation-related genes and stemness-related genes in cancer cells	[45]
	HAS2	Triggers the progression of cancer	[47]
	MMP3 and MMP9	Promotes the tumorigenesis and growth	[48]
	PI3K/Akt	Contributes to cisplatin resistance in NSCLC cells	[49]
Breast cancer	AEP	Promotes the intracellular stability and metastasis	[50]
	SET8	Increases the proliferation of breast cancer cells	[53]
	Snail, Slug and Twist	Promotes EMT and breast cancer metastasis; cancer stem cell-like characteristics of breast cancer cells	[54, 56]
	CDC25A	Promotes cell cycle progression	[58]
	Geminin	Enhances genomic instability, DNA replication change, aneuploidy, and cancer progression	[61]
	MAPK signaling pathway	Decreases the cell viability	[62]
Gastrointestinal cancer	H2AX	Overcomes DNA double-strand break (DSB)	[66, 68]
	DEC1	Recovers from G2 DNA damage checkpoint	[69]
	Nrf2	Leads to chemotherapy resistance	[70]
Genitourinary cancer	NF-κB/ROS	Promotes the proliferation, migration, and invasion of prostate cancer cells and inhibits apoptosis	[72]
Genitourinary cancer	BRD4	Leads to drug resistance of BET inhibitor	[73]
Gynecologic cancer	SDS3	Induces apoptosis and inhibits cell proliferation in cervical adenocarcinoma cells	[74]
	Ras	Decreases growth of Hela cells	[77]
	ELK-1	Promotes cell proliferation	[80]
	Rho GTPases	Promotes cell migration and cytoskeleton reorganization	[81]
	MCL1	Regulates chemoresistance in ovarian cancer	[85]
Bone and soft tissue sarcomas	Smad4	Enhances the migration and invasion of osteosarcoma cells through activation of EMT	[86]

AEP asparaginyl endopeptidase, Akt protein kinase B, BET bromodomain and extra-terminal domain, BRD4 bromodomain-containing protein 4, CDC25A cell division cycle 25A, DEC1 defective chorion-1, EGFR epidermal growth factor receptor, ELK-1 ETS-like protein 1, EZH2 enhancer of zeste homolog-2, H2AX H2A histone family member X, HAS2 hyaluronan synthase 2, MAPK mitogen-activated protein kinase, MCL1 myeloid cell leukemia sequence 1, MMP3 matrix metallopeptidase 3, OSCC oral squamous cell carcinoma, PI3K phosphoinositide-3-kinase, ROS reactive oxygen species, SDS3 suppressor of defective silencing 3, SET8 SET domain-containing protein 8, TRAFs tumor necrosis factor receptor associated factors

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ISSN: 1475-2867

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