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Fig. 4 | Cancer Cell International

Fig. 4

From: USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

Fig. 4

Changes in cell cycle of 786-O and ACHN cells after USP39 knockdown and the effect of USP39 on angiogenesis. A The S-phase peaks and subG1 phase peaks of 786-O and ACHN cells were significantly upregulated. B, C The proportion of S-phase cells, subG1 phase cells and G0/G1 phase cells in 786-O and ACHN cells after USP39 knockdown. D Tubular formation and analysis after USP39 knockdown or overexpression. EG Tubular formation and tubule branching analysis of HUVECs after USP39 knockdown or overexpression. *P < 0.05; **P < 0.01 versus Lv + shCon or Lv + oeCon. *P < 0.05, **P < 0.01, ***P < 0.001 versus Lv + shCon

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