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Table 2 Univariate and multivariate cox regression analysis of OS of Zhao renal dataset

From: USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

 

Univariate cox regression

Multivariate cox regression

HR (95% CI)

p value

HR (95% CI)

p value

Agea, years

 

0.125

 

0.871

 < 67

1.00 (referent)

 

1.00 (referent)

 

 ≥ 67

1.344 (0.921–1.959)

 

1.033 (0.701–1.522)

 

Sex

 

0.736

 

0.491

 Male

1.00 (referent)

 

1.00 (referent)

 

 Female

0.937 (0.642–1.367)

 

1.151 (0.771–1.718)

 

TNM stage

 

0.000

 

0.000

 I + II

1.00 (referent)

 

1.00 (referent)

 

 III + IV

4.279 (2.771–6.607)

 

3.812 (2.382–6.101)

 

Fuhrman grade

 

0.013

 

0.683

 1 + 2

1.00 (referent)

 

1.00 (referent)

 

 3 + 4

1.866 (1.138–3.060)

 

1.114 (0.664–1.868)

 

WHO performance status

 

0.000

 

0.000

 0

1.00 (referent)

 

1.00 (referent)

 

 1 or greater

2.460 (1.608–3.763)

 

2.216 (1.419–3.460)

 

USP39 expression

 

0.007

 

0.014

 Low

1.00 (referent)

 

1.00 (referent)

 

 High

1.680 (1.150–2.455)

 

1.629 (1.103–2.405)

 
  1. Univariate and multivariate analyses showed that the level of USP39 expression was an independent risk factor for overall survival in renal cancer patients
  2. OS overall survival
  3. aDivided at median
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Cancer Cell International

ISSN: 1475-2867

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