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Table 2 Univariate and multivariate cox regression analysis of OS of Zhao renal dataset

From: USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

  Univariate cox regression Multivariate cox regression
HR (95% CI) p value HR (95% CI) p value
Agea, years   0.125   0.871
 < 67 1.00 (referent)   1.00 (referent)  
 ≥ 67 1.344 (0.921–1.959)   1.033 (0.701–1.522)  
Sex   0.736   0.491
 Male 1.00 (referent)   1.00 (referent)  
 Female 0.937 (0.642–1.367)   1.151 (0.771–1.718)  
TNM stage   0.000   0.000
 I + II 1.00 (referent)   1.00 (referent)  
 III + IV 4.279 (2.771–6.607)   3.812 (2.382–6.101)  
Fuhrman grade   0.013   0.683
 1 + 2 1.00 (referent)   1.00 (referent)  
 3 + 4 1.866 (1.138–3.060)   1.114 (0.664–1.868)  
WHO performance status   0.000   0.000
 0 1.00 (referent)   1.00 (referent)  
 1 or greater 2.460 (1.608–3.763)   2.216 (1.419–3.460)  
USP39 expression   0.007   0.014
 Low 1.00 (referent)   1.00 (referent)  
 High 1.680 (1.150–2.455)   1.629 (1.103–2.405)  
  1. Univariate and multivariate analyses showed that the level of USP39 expression was an independent risk factor for overall survival in renal cancer patients
  2. OS overall survival
  3. aDivided at median