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Table 5 Univariate and multivariate analysis for prediction of LAG-3 expression in all patients

From: Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Variables Univariate Multivariate
OR 95% CI p value OR 95% CI p value
Age
(< 60 y vs. ≥ 60 y)
0.501 0.199–1.263 0.143 0.604 0.214–1.703 0.131
Sex
(female vs. male)
1.757 0.805–3.833 0.157    
Smoking status
(nonsmoker vs. smoker)
0.990 0.372–2.636 0.985    
Pathological type
(I–II vs. III)
0.630 0.266–1.492 0.294    
EBV status
(negative vs. positive)
0.632 0.282–1.413 0.263    
Family history
(yes vs. no)
2.123 0.837–5.384 0.113 2.238 0.786–6.373 0.131
Disease stage
(I–II vs. III–IV)
0.743 0.300–1.843 0.522    
PD-1 expression on TILs
(Low vs. High)
2.535 1.157–5.551 0.020 2.282 0.970–5.367 0.059
PD-L1 expression on TC
(Low vs. High)
2.400 0.684–8.418 0.113 0.271 0.105–0.695 0.007
PD-L1 expression on TILs
(Low vs. High)
0.513 0.225–1.170 0.005 3.439 1.280–9.237 0.014
CD3+ TIL
(Low vs. High)
1.875 0.878–4.006 0.105 1.317 0.546–3.175 0.540
GZMB
(Low vs. High)
2.167 0.785–5.979 0.135 1.476 0.482–4.520 0.495
  1. All the p values marked in bold are less than 0.05, which is statistically significant
  2. LAG-3: lymphocyte activating 3; CI: confidence interval; PD-L1: programmed death ligand 1; PD-1: programmed death 1; TIL: tumor-infiltrating lymphocyte; TC: tumor cells; GZMB: granzyme B; EBV: Epstein-Barr virus; CI: confidence interval; OR: odds ratio