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Table 6 COX regression analysis of DFS

From: Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Variables Univariate Multivariate
HR 95% CI p value HR 95% CI p value
Age
(≥ 60 vs. < 60 y)
1.588 1.024–2.462 0.039 1.222 0.779–1.916 0.382
Sex
(Female vs. Male)
1.006 0.717–1.412 0.972    
Smoking status
(Nonsmoker vs. Smoker)
1.049 0.708–1.554 0.813    
Pathological type
(I–II vs. III)
0.696 0.495–0.977 0.036 0.693 0.484–0.992 0.045
EBV status
(Negative vs. Positive)
0.838 0.614–1.144 0.267    
Family history
(Yes vs. No)
0.942 0.619–1.433 0.780    
Disease stage
(III–IV vs. I–II)
1.051 0.747–1.479 0.773    
LAG-3 expression on TILs
(Low vs. High)
0.441 0.296–0.657  < 0.001 0.434 0.284–0.663  < 0.001
PD-1 expression on TILs
(Low vs. High)
0.494 0.363–0.671  < 0.001 0.558 0.400–0.778 0.001
PD-L1 expression on TC
(Low vs. High)
0.659 0.455–0.953 0.027 0.636 0.432–0.937 0.022
PD-L1 expression on TILs
(Low vs. High)
0.678 0.452–1.017 0.002 1.050 0.667–1.654 0.832
CD3+ TIL
(Low vs. High)
1.179 0.731–1.900 0.499    
GZMB
(Low vs. High)
0.661 0.467–0.936 0.063 1.119 0.757–1.653 0.574
  1. All the p values marked in bold are less than 0.05, which is statistically significant
  2. LAG-3: lymphocyte activating 3; PD-L1: programmed death ligand 1; PD-1: programmed death 1; GZMB: granzyme B; TIL: tumor-infiltrating lymphocyte; TC: tumor cells; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval