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Fig. 5 | Cancer Cell International

Fig. 5

From: The role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network

Fig. 5

ER stress-induced apoptosis was partly inhibited by KCNQ1OT1/XIST. A HCT116 cells were treated with tunicamycin (TM), an activator of ER stress, and transfected with Ov-KCNQ1OT1 or Ov-XIST. TUNEL assay was conducted to determine cell apoptosis. B The expression level of GRP78 was detected by qRT-PCR. C The protein expression of XBP-1 s, XBP-1u, Bcl-2, cleaved caspase3 and capase3 were detected using western blot. ***p < 0.001 vs. TM; ##p < 0.01 vs. TM + Ov NC

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Cancer Cell International

ISSN: 1475-2867

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