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Fig. 7 | Cancer Cell International

Fig. 7

From: The role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network

Fig. 7

The directly targeted miRNAs of XBP-1 and KCNQ1OT1/XIST. A HCT116 cells were co-transfected with KCNQ1OT1 WT/KCNQ1OT1 MUT and miR-500a-3p/miR-370-3p/miR-2467-3p/miR-512-3p mimic, and the relative luciferase activity was determined using luciferase reporter assay. ***p<0.001 vs KCNQ1OT1 WT. B HCT116 cells were co-transfected with XIST WT/XIST MUT and miR-500a-3p/miR-370-3p/miR-2467-3p/miR-512-3p mimic, and the relative luciferase activity was determined using luciferase reporter assay. ***p < 0.001 vs XIST WT. C HCT116 cells were co-transfected with XBP-1u WT/ XBP-1u MUT and miR-500a-3p/miR-370-3p/miR-2467-3p/miR-512-3p mimic, and the relative luciferase activity was determined using luciferase reporter assay. ***p < 0.001 vs XBP-1u WT. D HCT116 cells were co-transfected with XBP-1s WT/ XBP-1s MUT and miR-500a-3p/miR-370-3p/miR-2467-3p/miR-512-3p mimic, and the relative luciferase activity was determined using luciferase reporter assay

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