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Table 2 Antisense LncRNAs are related to drug resistance in cancer

From: The regulatory role of antisense lncRNAs in cancer

Antisense LncRNA Cancer type Drug Mechanism Refs
HOXD-AS1 Cervical cancer Cisplatin HOXD-AS1 enhances chemoresistance of cisplatin-resistant cancer cells by modulating miR-130a-3p/ZEB1 axis [142]
DLX6-AS1 Breast cancer   DLX6-AS1 promotes cisplatin resistance through miR-199b-5p/PXN signaling [143]
NCK1-AS1 Osteosarcoma   NCK1-AS1 knockdown enhances Cisplatin sensitivity of cancer cells by regulating miR-137 [144]
SLC7A11-AS1 Pancreatic cancer Gemcitabine SLC7A11-AS1 promotes Gemcitabine-resistance by Blocking SCF β-TRCP-Mediated Degradation of NRF2 [145]
SBF2-AS1 Pancreatic cancer   SBF2-AS1 promotes the expression of TWF1 by binding with miR-142-3p to induce gemcitabine resistance [146]
LOXL1-AS1 Prostate cancer Doxorubicin LOXL1-AS1/miR-let-7a-5p/EGFR-related pathway regulates the doxorubicin resistance [147]
FOXC2-AS1 Osteosarcoma   FOXC2-AS1 promotes doxorubicin resistance by increasing the expression of FOXC2 [148]
AFAP1-AS1 Breast cancer Trastuzumab AFAP1-AS1 promotes trastuzumab resistance by binding with AUF1 and activating ERBB2 expression [149]
SBF2-AS1 Glioblastoma Temozolomide SBF2-AS1 enhances chemoresistance to temozolomide by functioning as a ceRNA for miR-151a-3p [150]
ADAMTS9-AS2 Glioblastoma   ADAMTS9-AS2 promotes Temozolomide Resistance via Upregulating the FUS/MDM2 Ubiquitination Axis [151]
NR2F1-AS1 Liver cancer Oxaliplatin NR2F1-AS1 regulates oxaliplatin resistance by targeting ABCC1 via miR-363 [152]
DSCAM-AS1 Breast cancer Tamoxifen DSCAM-AS1 enhances Tamoxifen resistance by functioning as a sponge of miR-137 [153]
ADAMTS9-AS2 Breast cancer   ADAMTS9-AS2 enhances tamoxifen resistance by activating miR-130a-5p [154]
AFAP1-AS1 Prostate cancer Paclitaxel AFAP1-AS1 modulates the sensitivity of paclitaxel via miR-195-5p/FKBP1A axis [155]
DDX11-AS1 Esophageal cancer   DDX11-AS1 promotes resistance cancer cells to Paclitaxel by inhibiting TOP2A expression via TAF1 [156]