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Table 2 The subgroup analysis of the prevalence of ATM variants in patients with breast cancerbased on ATM variants, BRCA status, and continents

From: The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis

Variables

Subgroups

Pooled prevalence (% 95 CI)

Heterogeneity assessment

Isquare (%)

Q

P Heterogeneity

ATM variant

All

6% (4–8%)

94

289

0.00

Deletion

0% (0–1%)

0

1

0.59

Insertion

2% (4–9%)

67

3

0.08

Substitution

12% (7–18%)

99

743

0.00

BRCA status

Positive

11% (7–15%)

99

604

0.00

Negative

3% (2–4%)

85

107

0.00

Not determined

12% (6–18%)

98

336

0.00

Continents (population)

American

9% (4–14%)

96

125

0.00

Asian

5% (1–11%)

80

10

0.01

European

7% (5–8%)

98

939

0.00