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Table 2 The subgroup analysis of the prevalence of ATM variants in patients with breast cancerbased on ATM variants, BRCA status, and continents

From: The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis

Variables Subgroups Pooled prevalence (% 95 CI) Heterogeneity assessment
Isquare (%) Q P Heterogeneity
ATM variant All 6% (4–8%) 94 289 0.00
Deletion 0% (0–1%) 0 1 0.59
Insertion 2% (4–9%) 67 3 0.08
Substitution 12% (7–18%) 99 743 0.00
BRCA status Positive 11% (7–15%) 99 604 0.00
Negative 3% (2–4%) 85 107 0.00
Not determined 12% (6–18%) 98 336 0.00
Continents (population) American 9% (4–14%) 96 125 0.00
Asian 5% (1–11%) 80 10 0.01
European 7% (5–8%) 98 939 0.00