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Fig. 5 | Cancer Cell International

Fig. 5

From: The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer

Fig. 5

Avasimibe-induced inhibition of cell migration and proliferation was partially rescued by E2F-1 knockdown. a qRT-PCR affirmed the interfering efficiency of E2F-1 in PCa cells (DU 145, PC-3); b MTT assays showed that inhibition of cell proliferation was partially rescued by E2F-1 knockdown in DU 145 cells; c results of MTT assays in PC-3 cells; d clonogenic survival assays showed that inhibition of colony formation was partially rescued by E2F-1 knockdown in DU 145 and PC-3 cells; e the quantitative results of clonogenic survival assays; f Transwell assays revealed that inhibition of cell migration could be rescued by E2F-1 knockdown; g statistical analysis of the results of transwell assays; h western blots of the EMT-related protein N-cadherin, Vimentin, E-cadherin and Snail in DU 145 and PC-3 cells after avasimibe treatment and E2F-1 knockdown; i mechanism diagram. *p < 0.05, **p < 0.01, ***p < 0.001, the scale bar is 1 cm

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Cancer Cell International

ISSN: 1475-2867

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