Fig. 6

Exploration of regulatory mechanism of POLQ on HCC. A, B A human apoptosis signaling array was used to detect the difference in the phosphorylation level of various apoptosis related signaling pathways. C The proteins with significantly differential phosphorylation level were shown for clearer demonstration. D The expression of ERK, JNK1, PRAS40, p-Stat3 and p-HSP27 was detected in both cell lines with or without POLQ knockdown. E Expression levels of several tumor-related factors were detected by western blotting. Data = mean ± SD (n ≥ 3). * P < 0.05, ** P < 0.01, *** P < 0.001