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Fig. 3 | Cancer Cell International

Fig. 3

From: LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer

Fig. 3

Knockdown of LINC01605 impairs the colony formation of CC cells. ShRNAs targeting LINC01605 (shRNA-1 and shRNA-2) were transfected into LoVo and Caco-2 cells. A LINC01605 expression in cells measured by RT-qPCR. B the number of colonies formed by LoVo and Caco-2 examined using colony formation assay. C the proliferative activity of LoVo and Caco-2 examined using CCK-8 assay. D the proportion of apoptotic cells in LoVo and Caco-2 cells measured using flow cytometry. E the number of apoptosis bodies in cells examined using TUNEL assay. F, G the altered migration and invasion ability of LoVo and Caco-2 cells measured using Transwell assay. H the number of tubes formed by HUVEC cells co-cultured with Caco-2 and LoVo cells evaluated using tube formation assay. Error bars represent means ± SD for three independent experiments (**p < 0.01, two-way ANOVA, followed by Tukey’s multiple comparison)

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