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Fig. 8 | Cancer Cell International

Fig. 8

From: LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer

Fig. 8

SPTBN2 overexpression reverses the repressive effects of LINC01605 silencing on CC cells. Overexpression plasmid of SPTBN2 was transfected into cells with stable low expression of LINC01605. A SPTBN2 protein expression in cells after co-transfection by Western blot. B the number of colonies formed by LoVo and Caco-2 examined using colony formation assay. C the proliferative activity of LoVo and Caco-2 examined using CCK-8 assay. D the proportion of apoptotic cells in LoVo and Caco-2 cells by flow cytometry. E the number of apoptosis bodies in cells by TUNEL assay. F, G the altered migration and invasion ability of LoVo and Caco-2 cells by Transwell assay. H the number of tubes formed by HUVEC cells co-cultured with Caco-2 and LoVo cells by tube formation assay. Error bars represent means ± SD for three independent experiments (**p < 0.01, two-way ANOVA, followed by Tukey’s multiple comparison)

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Cancer Cell International

ISSN: 1475-2867

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