Table 3 CircRNAs with tumor suppressive functions in RCC
From: Circular RNAs and their role in renal cell carcinoma: a current perspective
CircRNA | Target miRNA/gene axis | Gene/protein activity | Functions in RCC | Ref |
|---|---|---|---|---|
hsa-circ0072309 | miR-100/PI3K/AKT/mTOR | Increased | Increased proliferation, migration and invasion; decreased apoptosis | [86] |
circ0001451 | – | – | Increased proliferation; decreased apoptosis | [81] |
circAKT3 | miR-296-3p/E-cadherin | Decreased | Increased migration, invasion and EMT | [87] |
cRAPGEF5 | miR-27a-3p/TXNIP | Decreased | Increased proliferation,migration and invasion | [71] |
circATP2B1 | miR-204-3p/FN1 | Increased | Increased migration and invasion | [88] |
circHIAT1 | miR-195-5p miR-29a-3p miR-29c-3p/CDC42 | Increased | Increased migration and invasion | [89] |
circMTO1 | miR9/LMX1A | Decreased | Increased proliferation and invasion | [90] |