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Fig. 7 | Cancer Cell International

Fig. 7

From: Immune classifier-based signatures provide good prognostic stratification and predict the clinical benefits of immune-based therapies for hepatocellular carcinoma

Fig. 7

PPI network analysis, the identification of five key immune system-related genes, and a prognostic model based on these five genes. a The PPI network analysis revealed four hub genes (IL6, CCR3, SAA1, and GCG) that were closely related to the immune classifier-based DEGs. be qRT-PCR was performed to determine the relative expression of IL6, CCR3, SAA1, and GCG in the HCC cell line (Hep3B) and the control cell line (L02). f The key immune system-related genes (SEMA3A, TNFRSF11B, GUCA2A, SAA1, and CALCR) and the prognostic model based on these genes demonstrated that the group with high risk scores had shorter overall survival times than the group with low risk scores. g The biomarkers were validated using the ICGC-LIRI-JP dataset. The five-gene-based prognostic model showed that the group with high risk scores had worse prognoses than the group with low risk scores. h Area under the curve (AUC) analyses showed that this predictive model demonstrated good prognostic value

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