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Fig. 6 | Cancer Cell International

Fig. 6

From: Long noncoding RNA LINC00958 suppresses apoptosis and radiosensitivity of colorectal cancer through targeting miR-422a

Fig. 6

LINC00958 promotes MAPK1 expression and progression of colorectal cancer through miR-422a. a Pearson’s correlation showed that LINC00958 level positively correlated with MAPK1 level in 63 paired colorectal cancer tissues (R = 0.6412, p < 0.001). b The expression of MAPK1 protein (ERK1/2, pERK1/2), Bcl-2 and Bax after knockdown of LINC00958 and miR-422a in SW480 cells. c The mRNA expression of MAPK1 after knockdown of LINC00958 and miR-422a in SW480 cells. d The relative luciferase activity of wild type of MAPK1 mRNA 3’-UTR after knockdown of LINC00958 and miR-422a in SW480 cells. e The results of flow cytometry assay after knockdown of LINC00958 and miR-422a in SW480 cells. f, g The CCK-8 (f) and MTT (g) results after knockdown of LINC00958 and miR-422a in SW480 cells. h The survival fraction under different irradiation dose after knockdown of LINC00958 and miR-422a in SW480 cells. Data are reported as means ± standard deviation of three independent experiments. **p < 0.01

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