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Fig. 2 | Cancer Cell International

Fig. 2

From: LncRNA MIR99AHG mediated by FOXA1 modulates NOTCH2/Notch signaling pathway to accelerate pancreatic cancer through sponging miR-3129-5p and recruiting ELAVL1

Fig. 2

FOXA1 serves as a transcription activator of MIR99AHG. A, B RT-qPCR detected MIR99AHG expression when KLF4 or FOXA1 was knocked down or overexpressed. C JASPAR was applied for prediction of the binding motif of FOXA1 and 2 potential binding sites between FOXA1 and MIR99AHG promoter. D, E ChIP and luciferase reporter assay validated the binding between FOXA1 and MIR99AHG promoter. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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