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Fig. 7 | Cancer Cell International

Fig. 7

From: LncRNA MIR99AHG mediated by FOXA1 modulates NOTCH2/Notch signaling pathway to accelerate pancreatic cancer through sponging miR-3129-5p and recruiting ELAVL1

Fig. 7

Down-regulation of miR-3129-5p or up-regulation of NOTCH2 rescues the abrogated PCa cell malignant behaviors imposed by MIR99AHG knockdown. A NOTCH2 was overexpressed in SW1990 cells. B, C Cell proliferation was observed in SW1990 cells with the transfection of indicated plasmids including sh-NC, sh-MIR99AHG#1, sh-MIR99AHG#1 + NC inhibitor, sh-MIR99AHG#1 + miR-3129-5p inhibitor, sh-MIR99AHG#1 + pcDNA3.1 and sh-MIR99AHG#1 + pcDNA3.1/NOTCH2 through colony formation assay and EdU assay. D, E The evaluation of cell migration in different transfection conditions was done by means of wound healing and transwell assays. F Transwell assays were applied to conduct investigation in the invasive capacity of SW1990 cells in different groups. *P < 0.05, **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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