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Table 1 Summary of patient characteristics and clusters identified by t-distributed stochastic neighbor embedding (t-SNE)

From: Single cell RNA-seq data and bulk gene profiles reveal a novel signature of disease progression in multiple myeloma

Sample IDs Total number of cells analyzed Cluster 0 Cluster 1 Cluster 2 Cluster 3 Cluster 4 Cluster 5 Cluster 6 Cytogenetic abnormality
IgM MGUS1 24 1(4%) 21(88%) 1(4%) 0 0 1(4%) 0 Not tested
IgM MGUS3 17 0 17(100%) 0 0 0 0 0 Not tested
MGUS5 7 0 6(86%) 0 0 0 1(14%) 0 Normal
SMM0 77 0 0 76(99%) 0 0 0 1(1%) t(4;14), gain 1q21, del 13q
SMM2 16 1(6%) 15(94%) 0 0 0 0 0 t(14;20), monosomy 13
SMM3 39 36(92%) 3(8%) 0 0 0 0 0 Trisomy 7,9,11 and 15
SMM4 44 43(98%) 1(2%) 0 0 0 0 0 Trisomy 3, 7,9,11 14, & 15
NDMM3 59 10(17%) 2(3%) 0 47(80%) 0 0 0 Trisomy 3,7,& 11, trisomy/tetrasomy 9 & 15
NDMM5 32 28(88%) 4(13%) 0 0 0 0 0 Trisomy 7,9,11, &14, trisomy/tetrasomy 3 & 15, del 13q
NDMM6 47 46(98%) 1(2%) 0 0 0 0 0 Trisomy 3, 9, 11, &15
NDMM7 54 0 54(100%) 0 0 0 0 0 t(11;14)
NDMM8 60 59(98%) 1(2%) 0 0 0 0 0 Trisomy 3, 8, 9, &14, trisomy/tetrasomy 7, tetrasomy 11, gain 1q21
RRMM1 46 0 0 0 0 46(100%) 0 0 t(4;14), monosomy 13, del 17p
RRMM2 42 1(2%) 2(5%) 2(5%) 0 0 37(88%) 0 t(4;14), trisomy 11 & 15, monosomy 9 & 13
RRMM4 33 0 0 0 0 0 0 33(100%) t(11;14) and tetraploid
Total 597 225(38%) 127(21%) 79(13%) 84(14%) 46(8%) 2(0%) 34(6%)  
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Cancer Cell International

ISSN: 1475-2867

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