Variables | Univariate analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Training set GSE24080 | ||||||
20-gene risk model (high/low) | 4.337 | 3.206–5.868 | 1.83e−21* | 3.532 | 2.625–4.87 | 1.38e−14* |
Age (y) | 1.024 | 1.007–1.041 | 5.21e−03* | 1.009 | 0.992–1.026 | 0.315 |
Sex (male/female) | 0.971 | 0.716–1.317 | 0.850 | – | – | – |
IgA_Isotype (Y/N) | 1.093 | 0.777–1.537 | 0.609 | – | – | – |
Serum β2MG ≥ 3.5 mg/L (Y/N) | 2.211 | 1.633–2.994 | 2.92e−07* | 1.548 | 1.034–2.32 | 0.034* |
CRP ≥ 8.0 mg/L (Y/N) | 1.485 | 1.096–2.011 | 0.011* | 1.14 | 0.822–1.58 | 0.433 |
sCr ≥ 2.0 mg/L (Y/N) | 2.746 | 1.866–4.039 | 2.93e−07* | 1.442 | 0.929–2.237 | 0.102 |
LDH > upper limit of normal (> 190 U/L) (Y/N) | 2.32 | 1.716–3.137 | 4.57e−08* | 1.502 | 1.078–2.093 | 0.016* |
Serum ALB < 3.5 g/L (Y/N) | 1.927 | 1.329–2.794 | 5.41e−04* | 1.255 | 0.835–1.886 | 0.274 |
Hemoglobin < 100 g/L (Y/N) | 1.625 | 1.191–2.216 | 2.17e−03* | 0.982 | 0.693–1.391 | 0.916 |
Bone marrow plasma cells (%) | 1.01 | 1.004–1.016 | 9.14e−04* | 1 | 0.993–1.007 | 0.952 |
Validation set GSE9782 | ||||||
20-gene risk model (high/low) | 2.737 | 2.11–3.55 | 3.33e−14* | 3.017 | 2.162–4.211 | 8.35e−11* |
Serum β2M ≥ 3.5 mg/L (Y/N) | 1.961 | 1.315–2.924 | 9.6e−04* | 1.686 | 1.098–2.588 | 0.017* |
CRP ≥ 8.0 mg/L (Y/N) | 2.107 | 1.416–3.135 | 2.36e−04* | 1.6 | 1.057–2.423 | 0.026* |
Serum ALB < 3.5 g/L (Y/N) | 1.798 | 1.298–2.49 | 4.17e−04* | 1.618 | 1.058–2.476 | 0.026* |