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Table 2 The characteristics of circRNAs in CRC as a chemotherapy resistance

From: The effective function of circular RNA in colorectal cancer

CircRNA

GENE related miRNA

Expression

Targeted molecules/pathways

Function

References (DOI)

Year

Hsa_circ_0079662

 

Up

TNF-α

HOXA9

Induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway

[66]

2020

Hsa_circ_0005963

miR-122

Up

PKM2

chemoresistance. In vitro and in vivo

[69]

2020

Circ_0007031

miR-760

Up

DCP1A

Regulate the Growth and Chemoradiotherapy Resistance

[84]

2020

CircDDX17

miR-31-5p

Down

KANK1

Tumor suppressor

Strengthened chemosensitivity of CRC to 5-Fu

[131]

2020

Circ-PRKDC

miR-375

Up

FOXM1 Axis and WBT/β-Catenin

Enhanced 5-FU resistance in CRC

[85]

2020

Circ-0001313

mir-3383p

mir33b5p

mir935p

Up

Ccdc66

Promote resistance to radiotherapy and 5fu

[124]

2019

Circ 32,883

Mir501-5p

Up

EmL5

Promote resistance to folfox

 

2019

Circ0007006

Mir300

653-5p

628-5p

Up

 

Promote resistance to 5fu

[122]

2017

Circ0000504

Mir485-5p

Up

Tubgcp3

Stat3

Promote resistance to 5fu

[122]

2017