From: The effective function of circular RNA in colorectal cancer
CircRNA | GENE related miRNA | Expression | Targeted molecules/pathways | Function | References (DOI) | Year |
---|---|---|---|---|---|---|
Hsa_circ_0079662 | Up | TNF-α HOXA9 | Induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway | [66] | 2020 | |
Hsa_circ_0005963 | miR-122 | Up | PKM2 | chemoresistance. In vitro and in vivo | [69] | 2020 |
Circ_0007031 | miR-760 | Up | DCP1A | Regulate the Growth and Chemoradiotherapy Resistance | [84] | 2020 |
CircDDX17 | miR-31-5p | Down | KANK1 | Tumor suppressor Strengthened chemosensitivity of CRC to 5-Fu | [131] | 2020 |
Circ-PRKDC | miR-375 | Up | FOXM1 Axis and WBT/β-Catenin | Enhanced 5-FU resistance in CRC | [85] | 2020 |
Circ-0001313 | mir-3383p mir33b5p mir935p | Up | Ccdc66 | Promote resistance to radiotherapy and 5fu | [124] | 2019 |
Circ 32,883 | Mir501-5p | Up | EmL5 | Promote resistance to folfox | 2019 | |
Circ0007006 | Mir300 653-5p 628-5p | Up | Promote resistance to 5fu | [122] | 2017 | |
Circ0000504 | Mir485-5p | Up | Tubgcp3 Stat3 | Promote resistance to 5fu | [122] | 2017 |