Table 3 circRNAs with Biomarker potential in CRC

Hsa_circ_0002320

Down

Noninvasive diagnostic blood biomarker for CRC prognosis

[140]

2020

circMBOAT2

miR-519d-3p

Up

tissues

serum

TROAP)

A novel tumor marker and regulates proliferation/migration

[141]

2020

hsa_circ_0060927

Up

Potential diagnostic markers

[142]

2020

circ-CCDC66

miR-33b/miR-93/

Up

DNMT3B/EZH2/

MYC/YAP1

Promoting CRC growth and metastasis

[91]

2020

circ_0005075

Up

Wnt/β-catenin pathway

Potential target for the prognosis biomarker

[143]

2020

Hsa_circ_0004831

Up

WNT and p53 signaling pathway

Prognostic biomarker

[144]

2020

hsa_circ_104916

Down

Prognosis biomarker

Inhibiting CRC cell proliferation, migration, invasion, and inducing apoptosis

[145]

2019

hsa_circ_0004585

Up

Potential diagnostic biomarker for CRC

[146]

2019

hsa-circ-0004771

Up

Nvel potential diagnostic biomarker

[147]

2019

circ-PPP1R12A

Has-circ- 000,423

Up

Hippo/YAP Prognosis

Prognostic biomarker

Promoting pathogenesis and metastasis

[148]

2019

circ-MTO1

Down

WNT/β-catenin

Prognostic biomarker, Inhibiting cell proliferation and invasion

[149]

2018

hsa_circ_0001649

SHARE

Down

Novel diagnostic biomarker

Expression level is closely associated with pathological differentiation

[150]

2018

Has _circ_ 14,717

Down

P16

Prognostic biomarker

Inhibiting CRC cell proliferation, colony formation, and growth

[151]

2018

hsa_circ_0026344

miR-21/miR-31

Down

Prognostic biomarker

Inhibiting CRC cell growth and invasion and induces apoptosis

[45]

2018

Has-circ-0000711

Down

Diagnostic Prognostic biomarker

[152]

2018

Cirs-7

CDR1

EGFR/RAF1/MAPK pathway

Up

Mir-7

Prognostic biomarker

[27]

2018

hsa_circ_0000567

SETD3

Down

[153]

2018

hsa_circ_001988

FBXW7

Down

Potential diagnostic biomarker

[42]

2015

hsa_circ_0003906

Down

Diagnostic biomarker

[154]]

2015