Table 1 Clinical characteristics of PB-DHL patients (n = 48)
From: Primary breast double-hit lymphoma management and outcomes: a real-world multicentre experience
| Variable |
DA-EPOCH-R/MA (n, % ) |
DA-EPOCH-R (n, % ) |
R-HyperCVAD (n, % ) | P value |
|---|---|---|---|---|
| Age | 0.711 | |||
| ≤ 50 years | 9 (64.3) | 9 (50.0) | 10 (62.5) | |
| 50–60 years | 5 (35.7) | 9 (50.0) | 6 (37.5) | |
| Laterality | 0.965 | |||
| Right | 4 (28.6) | 7 (38.9) | 5 (31.3) | |
| Left | 7 (50.0) | 8 (44.4) | 7 (43.8) | |
| Bilateral | 3 (21.4) | 3 (16.7) | 4 (25.0) | |
| Tumour size | 0.811 | |||
| < 5 cm | 8 (57.1) | 11 (61.1) | 11 (68.8) | |
| ≥ 5 cm | 6 (42.9) | 7 (38.9) | 5 (31.3) | |
| Cell of origin | 0.890 | |||
| GCB | 11 (78.6) | 15 (83.3) | 14 (87.5) | |
| Non-GCB | 3 (21.4) | 3 (16.7) | 2 (12.5) | |
| Results of FISH | 0.745 | |||
| MYC-BCL2 | 10 (71.4) | 15 (83.3) | 13 (81.3) | |
| MYC-BCL6 | 4 (28.6) | 3 (16.7) | 3 (18.8) | |
| C-MYC of IHC | 1.000 | |||
| C-MYC (+) | 14 (100.0) | 18 (100.0) | 16 (100.0) | |
| BCL2 of IHC | 0.521 | |||
| BCL2 (+) | 13 (92.9) | 18 (100.0) | 15 (93.8) | |
| BCL6 of IHC | 0.767 | |||
| BCL6 (+) | 14 (100.0) | 16 (88.9) | 15 (93.8) | |
| CD5 of IHC | 0.406 | |||
| CD5 (+) | 5 (35.7) | 4 (22.2) | 7 (43.8) | |
| CD10 of IHC | 0.661 | |||
| CD10 (+) | 10 (71.4) | 10 (55.6) | 9 (56.3) | |
| P53 of IHC | 0.926 | |||
| P53 (+) | 9 (64.3) | 13 (72.2) | 11 (68.8) | |
| Ki-67 of IHC | 0.668 | |||
| Ki-67 ≥ 70 % | 12 (85.7) | 17 (94.4) | 15 (93.8) | |
| Chromosomal abnormality | 0.700 | |||
| Present | 3 (21.4) | 6 (33.3) | 3 (18.8) | |
| Ann Arbor Staging | 0.832 | |||
| IE | 4 (28.6) | 6 (33.3) | 3 (18.8) | |
| IIE | 7 (50.0) | 7 (38.9) | 7 (43.8) | |
| IV | 3 (21.4) | 5 (27.8) | 6 (37.5) | |
| B symptoms | 0.652 | |||
| Present | 10 (71.4) | 10 (55.6) | 10 (62.5) | |
| LDH level | 0.544 | |||
| Elevated | 5 (35.7) | 7 (38.9) | 9 (56.3) | |
| Risk stratification | 0.665 | |||
| L and L-I | 9 (64.3) | 9 (50.0) | 9 (56.3) | |
| H and H-I | 5 (35.7) | 9 (50.0) | 7 (43.8) | |
| ASCT | 0.811 | |||
| Yes | 6 (42.9) | 7 (38.9) | 5 (31.3) | |