From: Primary breast double-hit lymphoma management and outcomes: a real-world multicentre experience
Variable | DA-EPOCH-R/MA (n, % ) | DA-EPOCH-R (n, % ) | R-HyperCVAD (n, % ) | P value |
---|---|---|---|---|
Age | Â | Â | Â | 0.711 |
 ≤ 50 years | 9 (64.3) | 9 (50.0) | 10 (62.5) |  |
 50–60 years | 5 (35.7) | 9 (50.0) | 6 (37.5) |  |
Laterality | Â | Â | Â | 0.965 |
 Right | 4 (28.6) | 7 (38.9) | 5 (31.3) |  |
 Left | 7 (50.0) | 8 (44.4) | 7 (43.8) |  |
 Bilateral | 3 (21.4) | 3 (16.7) | 4 (25.0) |  |
Tumour size | Â | Â | Â | 0.811 |
 < 5 cm | 8 (57.1) | 11 (61.1) | 11 (68.8) |  |
 ≥ 5 cm | 6 (42.9) | 7 (38.9) | 5 (31.3) |  |
Cell of origin | Â | Â | Â | 0.890 |
 GCB | 11 (78.6) | 15 (83.3) | 14 (87.5) |  |
 Non-GCB | 3 (21.4) | 3 (16.7) | 2 (12.5) |  |
Results of FISH | Â | Â | Â | 0.745 |
 MYC-BCL2 | 10 (71.4) | 15 (83.3) | 13 (81.3) |  |
 MYC-BCL6 | 4 (28.6) | 3 (16.7) | 3 (18.8) |  |
C-MYC of IHC | Â | Â | Â | 1.000 |
 C-MYC (+) | 14 (100.0) | 18 (100.0) | 16 (100.0) |  |
BCL2 of IHC | Â | Â | 0.521 | |
 BCL2 (+) | 13 (92.9) | 18 (100.0) | 15 (93.8) |  |
BCL6 of IHC | Â | Â | Â | 0.767 |
 BCL6 (+) | 14 (100.0) | 16 (88.9) | 15 (93.8) |  |
CD5 of IHC | Â | Â | Â | 0.406 |
 CD5 (+) | 5 (35.7) | 4 (22.2) | 7 (43.8) |  |
CD10 of IHC | Â | Â | Â | 0.661 |
 CD10 (+) | 10 (71.4) | 10 (55.6) | 9 (56.3) |  |
P53 of IHC | Â | Â | Â | 0.926 |
 P53 (+) | 9 (64.3) | 13 (72.2) | 11 (68.8) |  |
Ki-67 of IHC | Â | Â | Â | 0.668 |
 Ki-67 ≥ 70 % | 12 (85.7) | 17 (94.4) | 15 (93.8) |  |
Chromosomal abnormality | Â | Â | Â | 0.700 |
 Present | 3 (21.4) | 6 (33.3) | 3 (18.8) |  |
Ann Arbor Staging | Â | Â | Â | 0.832 |
 IE | 4 (28.6) | 6 (33.3) | 3 (18.8) |  |
 IIE | 7 (50.0) | 7 (38.9) | 7 (43.8) |  |
 IV | 3 (21.4) | 5 (27.8) | 6 (37.5) |  |
B symptoms | Â | Â | Â | 0.652 |
 Present | 10 (71.4) | 10 (55.6) | 10 (62.5) |  |
LDH level | Â | Â | Â | 0.544 |
 Elevated | 5 (35.7) | 7 (38.9) | 9 (56.3) |  |
Risk stratification | Â | Â | Â | 0.665 |
  L and L-I | 9 (64.3) | 9 (50.0) | 9 (56.3) |  |
 H and H-I | 5 (35.7) | 9 (50.0) | 7 (43.8) |  |
ASCT | Â | Â | Â | 0.811 |
 Yes | 6 (42.9) | 7 (38.9) | 5 (31.3) |  |