Fig. 1
From: High temperature requirement A1 in cancer: biomarker and therapeutic target
The potential mechanisms underlying the effects of HTRA1 on EOC, BC and PC. In EOC, HtrA1 mediates apoptosis by inhibiting the levels of nuclear EGFR and XIAP, X-conjugated inhibitor of apoptosis proteins. In BC, PN-1 expression is regulated through the EGF/EGFR/PKCδ/MEK/ERK/EGR1 signaling pathway to inhibit the effect of the HTRA1 protein on tumors. In PC, HTRA1 directly inhibits the Notch-1 signaling pathway to regulate the tumor microenvironment