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Fig. 1 | Cancer Cell International

Fig. 1

From: High temperature requirement A1 in cancer: biomarker and therapeutic target

Fig. 1

The potential mechanisms underlying the effects of HTRA1 on EOC, BC and PC. In EOC, HtrA1 mediates apoptosis by inhibiting the levels of nuclear EGFR and XIAP, X-conjugated inhibitor of apoptosis proteins. In BC, PN-1 expression is regulated through the EGF/EGFR/PKCĪ“/MEK/ERK/EGR1 signaling pathway to inhibit the effect of the HTRA1 protein on tumors. In PC, HTRA1 directly inhibits the Notch-1 signaling pathway to regulate the tumor microenvironment

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