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Table 3 Detailed information of the proteins related to drug resistance of UCA1_sense and UCA1_antisense detected by protein MS after RNA pulldown

From: Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma

Identified by Protein ID Function Ref.
Both UCA1_sense and UCA1_antisense sp|P04406|G3P_HUMAN Inhibit cytarabine resistance of A549 cells [26]
sp|P07437|TBB5_HUMAN Be linked to paclitaxel chemoresistance of ovarian cancer cells [27]
sp|P25705|ATPA_HUMAN Lead to 5-FU resistance of colon cancer cells [28]
sp|P60174|TPIS_HUMAN Be an anti-drug resistance agent in gastric cancer [29]
sp|P00338|LDHA_HUMAN serve an important role in docetaxel resistance in castration‑resistant prostate cancer [30]
sp|P07737|PROF1_HUMAN Synergize with chemotherapeutic drugs to induce tumor cell death [31]
sp|P31943|HNRH1_HUMAN Result in acquired chemoresistance to thymidine phosphorylase activated fluoropyrimidine anticancer drugs [32]
sp|O43175|SERA_HUMAN Be a critical driver for sorafenib resistance in hepatocellular carcinoma [33]
sp|P15924|DESP_HUMAN Increase the sensitivity to anticancer drug-induced apoptosis in NSCLC [34]
sp|P04792|HSPB1_HUMAN Inhibit cell apoptosis induced by paclitaxel in ovarian cancer [35]
sp|P06733|ENOA_HUMAN Be a partner protein of fibroblast growth factor receptor‐like 1 promoting chemoresistance of small‐cell lung cancer [36]
UCA1_sense sp|Q8N163|CCAR2_HUMAN Promote drug resistance of colonospheres colon cancer cells [37]
sp|P11908|PRPS2_HUMAN Be a target gene regulated by miRNAs which co-regulate vincristine resistance in childhood acute lymphoblastic leukemia [38]
sp|Q13045|FLII_HUMAN Silencing of FLI1 sensitizes the resistant cells to BRAF inhibitors in melanoma cells [39]
sp|Q9Y6E2|BZW2_HUMAN Promote rapamycin resistance of hepatocellular carcinoma cells [40]
sp|P60981|DEST_HUMAN Be a differentially expressed protein related to platinum resistance in ovarian cancer [41]
sp|Q05639|EF1A2_HUMAN Inhibit chemotherapy-induced apoptosis resulting in chemoresistance [42]
sp|Q92769|HDAC2_HUMAN BE a target to overcome therapeutic resistance of adenocarcinoma against chemotherapeutics in pancreatic cancer [43]
sp|P51991|ROA3_HUMAN Be upregulated in cisplatin-resistant breast cancer cells [44]
sp|P33993|MCM7_HUMAN Be inhibited by simvastatin to suppress tamoxifen-resistant breast cancer cells growth [45]
sp|P14174|MIF_HUMAN As a therapeutic target for overcoming resistance to proteasome inhibitors in myeloma [46]
UCA1_antisense sp|P80723|BASP1_HUMAN Interact with oestrogen receptor α and modify the tamoxifen response in breast cancer [47]
sp|P14866|HNRPL_HUMAN Knockdown of HNRPL enhanced the level of DNA breakage and sensitivity of colorectal cancer cells to oxaliplatin [48]
sp|Q15019|SEPT2_HUMAN LncRNA FGD5-AS1/miR-497-5p/SEPT2 axis increased cisplatin-resistance in laryngeal squamous cell carcinoma [49]
sp|Q15717|ELAV1_HUMAN Contribute to TRAIL resistance by restricting death receptor 4 expression in pancreatic cancer [50]
sp|P13797|PLST_HUMAN Be a critical regulator of paclitaxel sensitivity of MDA-MB-231 cells [51]
sp|P21333|FLNA_HUMAN Modulate chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway [52]
sp|P06493|CDK1_HUMAN Cooperate with UBE2C to promote cisplatin resistance in ovarian cancer [53]
sp|P47929|LEG7_HUMAN Be a potential predictive marker of chemotherapy resistance in oral squamous cell carcinoma [54]
sp|Q8TEX9|IPO4_HUMAN Enhance cervical cancer cisplatin sensitivity [55]
sp|Q9P258|RCC2_HUMAN Block spontaneous- or staurosporine-induced apoptosis in three cancer cell lines [56]