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Table 3 Detailed information of the proteins related to drug resistance of UCA1_sense and UCA1_antisense detected by protein MS after RNA pulldown

From: Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma

Identified by

Protein ID

Function

Ref.

Both UCA1_sense and UCA1_antisense

sp|P04406|G3P_HUMAN

Inhibit cytarabine resistance of A549 cells

[26]

sp|P07437|TBB5_HUMAN

Be linked to paclitaxel chemoresistance of ovarian cancer cells

[27]

sp|P25705|ATPA_HUMAN

Lead to 5-FU resistance of colon cancer cells

[28]

sp|P60174|TPIS_HUMAN

Be an anti-drug resistance agent in gastric cancer

[29]

sp|P00338|LDHA_HUMAN

serve an important role in docetaxel resistance in castration‑resistant prostate cancer

[30]

sp|P07737|PROF1_HUMAN

Synergize with chemotherapeutic drugs to induce tumor cell death

[31]

sp|P31943|HNRH1_HUMAN

Result in acquired chemoresistance to thymidine phosphorylase activated fluoropyrimidine anticancer drugs

[32]

sp|O43175|SERA_HUMAN

Be a critical driver for sorafenib resistance in hepatocellular carcinoma

[33]

sp|P15924|DESP_HUMAN

Increase the sensitivity to anticancer drug-induced apoptosis in NSCLC

[34]

sp|P04792|HSPB1_HUMAN

Inhibit cell apoptosis induced by paclitaxel in ovarian cancer

[35]

sp|P06733|ENOA_HUMAN

Be a partner protein of fibroblast growth factor receptor‐like 1 promoting chemoresistance of small‐cell lung cancer

[36]

UCA1_sense

sp|Q8N163|CCAR2_HUMAN

Promote drug resistance of colonospheres colon cancer cells

[37]

sp|P11908|PRPS2_HUMAN

Be a target gene regulated by miRNAs which co-regulate vincristine resistance in childhood acute lymphoblastic leukemia

[38]

sp|Q13045|FLII_HUMAN

Silencing of FLI1 sensitizes the resistant cells to BRAF inhibitors in melanoma cells

[39]

sp|Q9Y6E2|BZW2_HUMAN

Promote rapamycin resistance of hepatocellular carcinoma cells

[40]

sp|P60981|DEST_HUMAN

Be a differentially expressed protein related to platinum resistance in ovarian cancer

[41]

sp|Q05639|EF1A2_HUMAN

Inhibit chemotherapy-induced apoptosis resulting in chemoresistance

[42]

sp|Q92769|HDAC2_HUMAN

BE a target to overcome therapeutic resistance of adenocarcinoma against chemotherapeutics in pancreatic cancer

[43]

sp|P51991|ROA3_HUMAN

Be upregulated in cisplatin-resistant breast cancer cells

[44]

sp|P33993|MCM7_HUMAN

Be inhibited by simvastatin to suppress tamoxifen-resistant breast cancer cells growth

[45]

sp|P14174|MIF_HUMAN

As a therapeutic target for overcoming resistance to proteasome inhibitors in myeloma

[46]

UCA1_antisense

sp|P80723|BASP1_HUMAN

Interact with oestrogen receptor α and modify the tamoxifen response in breast cancer

[47]

sp|P14866|HNRPL_HUMAN

Knockdown of HNRPL enhanced the level of DNA breakage and sensitivity of colorectal cancer cells to oxaliplatin

[48]

sp|Q15019|SEPT2_HUMAN

LncRNA FGD5-AS1/miR-497-5p/SEPT2 axis increased cisplatin-resistance in laryngeal squamous cell carcinoma

[49]

sp|Q15717|ELAV1_HUMAN

Contribute to TRAIL resistance by restricting death receptor 4 expression in pancreatic cancer

[50]

sp|P13797|PLST_HUMAN

Be a critical regulator of paclitaxel sensitivity of MDA-MB-231 cells

[51]

sp|P21333|FLNA_HUMAN

Modulate chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway

[52]

sp|P06493|CDK1_HUMAN

Cooperate with UBE2C to promote cisplatin resistance in ovarian cancer

[53]

sp|P47929|LEG7_HUMAN

Be a potential predictive marker of chemotherapy resistance in oral squamous cell carcinoma

[54]

sp|Q8TEX9|IPO4_HUMAN

Enhance cervical cancer cisplatin sensitivity

[55]

sp|Q9P258|RCC2_HUMAN

Block spontaneous- or staurosporine-induced apoptosis in three cancer cell lines

[56]