Fig. 3From: USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4 ARF4 binds to USP7 and is downregulated by USP7 inhibition A-C Proteins bound to USP7 were identified in SHG-140 by Co-IP and MS, and the screened proteins were analyzed for the KEGG pathway. D Heat map showing the comparative results of TMT proteomics analysis after 48 h treatment using DMSO or P5091 (2µM) in SHG-140. E Venn diagram showing down-regulated proteins in response to P5091 (yellow), USP7 interaction candidates identified by Co-IP (purple), and overlapping proteins. F Volcano plot showing the differential proteins from TMT proteomics analysis and the location of ARF4Back to article page