Fig. 3From: ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cellsALDOA decreased the percentage of cells in G2/M phase by suppressing ATM expression. A GSEA was conducted to analyse the signalling pathway enrichment in siALDOA PANC-1 and SW1990 cells compared with the NC group. B, C, D and E The mRNA and protein levels of ATM expression in ALDOA-silenced and ALDOA-overexpressing cell lines (PANC-1 and SW1990). F Confocal microscopy showed DNA damage (green) and nuclear DNA (blue) in ALDOA-silenced or normal cells (PANC-1 and SW1990) treated with siATM or siNC. G Cell cycle analysis by flow cytometry demonstrated an obvious change in the proportion of cells in G2/M phase in ALDOA-silenced or normal cells (PANC-1 and SW1990) treated with siATM or siNCBack to article page