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Fig. 3 | Cancer Cell International

Fig. 3

From: ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells

Fig. 3

ALDOA decreased the percentage of cells in G2/M phase by suppressing ATM expression. A GSEA was conducted to analyse the signalling pathway enrichment in siALDOA PANC-1 and SW1990 cells compared with the NC group. B, CD and E The mRNA and protein levels of ATM expression in ALDOA-silenced and ALDOA-overexpressing cell lines (PANC-1 and SW1990). F Confocal microscopy showed DNA damage (green) and nuclear DNA (blue) in ALDOA-silenced or normal cells (PANC-1 and SW1990) treated with siATM or siNC. G Cell cycle analysis by flow cytometry demonstrated an obvious change in the proportion of cells in G2/M phase in ALDOA-silenced or normal cells (PANC-1 and SW1990) treated with siATM or siNC

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