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Fig. 4 | Cancer Cell International

Fig. 4

From: ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells

Fig. 4

ALDOA promoted PLK1 activation by suppressing ATM expression. A and B The expression of ATM, phospho-PLK1-T210, PLK1 and ALDOA was determined by western blot analysis. C Dose-dependent effect of KU-55,933 treatment for 16 h on the phospho-PLK1-T210 and PLK1 protein. The expression of phospho-PLK1-T210 and PLK1 in PANC-1 or SW1990 cells treated with 10 ng/ml KU-55,933 over a time gradient. D and F PLK1 exerted significant regulation of the G2/M phase in cell cycle analysis by flow cytometry. E. The ALDOA group and the control group respectively were transfected by siPLK1 and siNC to assess colony formation capacity. G The expression of ALDOA, phospho-PLK1-T210 and PLK1 was determined by western blot analysis

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