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Table 1 Genotype frequencies of rs11016798, rs487120, rs557311 and rs1711654 and their associations with glioma risk

From: An insertion variant of MGMT disrupts a STAT1 binding site and confers susceptibility to glioma

Variants

Genotypea

Patients (n = 402)

No. (%)

Controls (n = 654)

No. (%)

ORb (95 %CI)

P

rs11016798

CC

135 (34.61)

186 (29.02)

1.00 (reference)

 

CT

201 (51.54)

318 (49.61)

0.90 (0.68–1.21)

0.491

TT

54 (13.85)

137 (21.37)

0.57 (0.39–0.85)

0.006

TT vs. CC + CT

  

0.61 (0.43–0.86)

0.005

rs487120

TT

152 (38.00)

265 (40.65)

1.00 (reference)

 

CT

190 (47.50)

294 (45.09)

1.13 (0.86–1.49)

0.385

CC

58 (14.50)

93 (14.26)

1.05 (0.71–1.56)

0.808

rs557311

GG

167 (41.75)

309 (47.61)

1.00 (reference)

 

AG

185 (46.25)

266 (40.99)

1.28 (0.98–1.68)

0.072

AA

48 (12.00)

74 (11.40)

1.13 (0.74–1.73)

0.580

rs1711654

TT

190 (47.62)

325 (50.31)

1.00 (reference)

 

CT

169 (42.36)

251 (38.85)

1.17 (0.89–1.53)

0.268

CC

40 (10.02)

70 (10.84)

1.01 (0.65–1.57)

0.963

  1. OR odds ratios, CI confidence interval
  2. aSome samples failed to genotype
  3. bData were calculated by logistic regression, adjusted for age and sex