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Fig. 2 | Cancer Cell International

Fig. 2

From: Midkine promotes glioblastoma progression via PI3K-Akt signaling

Fig. 2

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of MDK-related, GBM-specific genes. A Quadrant plot of identified MDK-related and/or GBM-specific genes. The x- and y-axes show the expression values of two groups of different genes, and quadrants 1, 2, 4, 6, 8 and 9 are the overlapped genes showing the same expression in the two groups. The upper quadrant and right quadrant represent the gene counts in different expression intervals. B Biological processes (BPs) in which MDK-related, GBM-specific genes were significantly involved, with a focus on processes of interest in GBM. C KEGG pathway in which MDK-related, GBM-specific genes were significantly involved, with a focus on pathways of interest in GBM. D The enrichment score for the PI3K-Akt signaling pathway was significantly higher in the MDK-high GBM samples than in the MDK-low samples. MDK: midkine; GBM: glioblastoma; GSVA: gene set variation analysis; BP: biological process; KEGG: Kyoto Encyclopedia of Genes and Genomes

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