Fig. 3

MDK-related regulation network in GBM. A The regulatory network of GBM development is regulated by MDK via TFs. The circle indicates pathway genes; the V shape, the signaling pathway; diamonds, TFs; and the square, MDK. B Molecular of MDK with four TFs: REST, TCF12, SP1 and XRN2. Docking energies (kcal/mol) are indicated below each complex; negative energies indicate that they may have a relationship. C MDK may regulate PI3K-Akt signaling by targeting TFs in GBM. The genes in this mechanism are the MDK-related, GBM-specific genes that are involved in the PI3K-Akt signaling pathway. The mechanism was adapted from the KEGG pathview, and lines are colored arbitrarily. MDK: midkine; GBM: glioblastoma; TF: transcription factor; KEGG: Kyoto Encyclopedia of Genes and Genomes